Chemoenzymatically synthesized multimeric Tn/STn MUC1 glycopeptides elicit cancer-specific anti-MUC1 antibody responses and override tolerance

Author:

Sørensen Anne Louise,Reis Celso A.,Tarp Mads A.,Mandel Ulla,Ramachandran Kavitha,Sankaranarayanan Vasanthi,Schwientek Tilo,Graham Ros,Taylor-Papadimitriou Joyce,Hollingsworth Michael A.,Burchell Joy,Clausen Henrik

Publisher

Oxford University Press (OUP)

Subject

Biochemistry

Reference56 articles.

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2. Adluri, S. , Gilewski, T., Zhang, S., Ramnath, V., Ragupathi, G., and Livingston, P. (1999) Specificity analysis of sera from breast cancer patients vaccinated with MUC1-KLH plus QS-21. Br. J. Cancer., 79, 1806–1812.

3. Backstrom, M. , Link, T., Olson, F.J., Karlsson, H., Graham, R., Picco, G., Burchell, J., Taylor-Papadimitriou, J., Noll, T., and Hansson, G.C. (2003) Recombinant MUC1 mucin with a breast cancer-like O-glycosylation produced in large amounts in Chinese-hamster ovary cells. Biochem. J., 376, 677–686.

4. Bartek, J. , Bartkova, J., Kyprianou, N., Lalani, E.N., Staskova, Z., Shearer, M., Chang, S., and Taylor-Papadimitriou, J. (1991) Efficient immortalization of luminal epithelial cells from human mammary gland by introduction of simian virus 40 large tumor antigen with a recombinant retrovirus. Proc. Natl. Acad. Sci. U. S. A., 88, 3520–3524.

5. Bennett, E.P. , Hassan, H., Mandel, U., Mirgorodskaya, E., Roepstorff, P., Burchell, J., Taylor-Papadimitriou, J., Hollingsworth, M.A., Merkx, G., van Kessel, A.G., and others. (1998) Cloning of a human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat. J. Biol. Chem., 273, 30472–30481.

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