Through the barricades: overcoming the barriers to effective antibody-based cancer therapeutics

Author:

Dalziel Martin1,Beers Stephen A2,Cragg Mark S2,Crispin Max34ORCID

Affiliation:

1. Oxford Glycobiology Institute, Department of Biochemistry, South Parks Road, Oxford, UK

2. Antibody & Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK

3. Centre for Biological Sciences, University of Southampton, Southampton, UK

4. Institute for Life Sciences, Highfield Campus, University of Southampton, Southampton, UK

Publisher

Oxford University Press (OUP)

Subject

Biochemistry

Reference189 articles.

1. High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules;Adams;Cancer Res,2001

2. Site-specific antibody-drug conjugates: The nexus of bioorthogonal chemistry, protein engineering, and drug development;Agarwal;Bioconjug Chem,2015

3. Trastuzumab biosimilar on track for approval;American Association for Cancer Research;Cancer Discov,2017

4. Biosimilars versus ‘biobetters’—a regulator’s perspective;Anour;GaBI J,2014

5. Identification of a receptor required for the anti-inflammatory activity of IVIG;Anthony;Proc Natl Acad Sci U S A,2008

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