Non-cigarette Tobacco Use and Stroke Among West Africans: Evidence From the SIREN Study-Reference-Cited by-同舟云学术

Non-cigarette Tobacco Use and Stroke Among West Africans: Evidence From the SIREN Study

Published:2023-11-28 Issue: Volume: Page:
ISSN:1469-994X
Container-title:Nicotine and Tobacco Research
language:en
Short-container-title:

Author:

Fakunle Adekunle Gregory¹²^ORCID,Okekunle Akinkunmi Paul¹³^ORCID,Asowata Osahon Jeffery⁴^ORCID,Akpa Onoja⁴⁵^ORCID,Sarfo Fred S⁶,Akpalu Albert⁷,Wahab Kolawole⁸,Obiako Reginald⁹,Komolafe Morenikeji¹⁰,Owolabi Lukman¹¹,Osaigbovo Godwin O¹²,Adeoye Abiodun M¹,Tiwari Hemant K¹³,Uvere Ezinne O¹,Akinyemi Joshua⁴,Jenkins Carolyn¹⁴,Arulogun Oyedunni¹⁵^ORCID,Ibinaiye Philip⁹,Appiah Lambert T⁶,Bello Temilade²,Singh Arti⁶^ORCID,Yaria Joseph¹,Calys-Tagoe Benedict¹⁶,Ogbole Godwin¹⁷,Chukwuonye Ijezie¹⁸,Melikam Chidinma⁹,Adebayo Philip¹⁹,Mensah Yaw²⁰,Adebayo Oladimeji¹⁵,Adeniyi Sunday⁸,Oguike Wisdom⁹,Donna Arnett²¹,Akinyemi Rufus²²²³²⁴,Ovbiagele Bruce²⁵,Owolabi Mayowa¹²⁴²⁶^ORCID

Affiliation:

1. Department of Medicine, College of Medicine, University of Ibadan , Ibadan , Nigeria

2. Department of Public Health, Osun State University , Osogbo , Nigeria

3. Department of Food and Nutrition, Seoul National University , Seoul , Korea

4. Department of Epidemiology and Medical Statistics, University of Ibadan , Ibadan , Nigeria

5. Institute of Cardiovascular Diseases, College of Medicine, University of Ibadan , Ibadan , Nigeria

6. Department of Medicine, Kwame Nkrumah University of Science and Technology , Kumasi , Ghana

7. Department of Medicine, University of Ghana Medical School , Accra , Ghana

8. Department of Medicine, University of Ilorin Teaching Hospital , Ilorin , Nigeria

9. Department of Radiology, Ahmadu Bello University , Zaria , Nigeria

10. Department of Medicine, Obafemi Awolowo University Teaching Hospital , Ile-Ife , Nigeria

11. Department of Medicine, Aminu Kano Teaching Hospital , Kano , Nigeria

12. Department of Medicine, Jos University Teaching Hospital , Jos , Nigeria

13. Department of Biostatistics, University of Alabama at Birmingham , Birmingham, AL , USA

14. Department of Nursing, Medical University of South Carolina , Charleston, SC , USA

15. Department of Health Promotion and Education, University of Ibadan , Ibadan , Nigeria

16. Department of Community Health, University of Ghana Medical School , Accra , Ghana

17. Department of Radiology, University of Ibadan , Ibadan , Nigeria

18. Department of Medicine, Federal Medical Centre , Umahia , Nigeria

19. Department of Internal Medicine, Aga-Khan University , Dar es Salaam , Tanzania

20. Department of Radiology, University of Ghana Medical School , Accra , Ghana

21. College of Public Health, University of Kentucky , Lexington, KY , USA

22. Department of Medicine, Federal Medical Centre , Abeokuta , Nigeria

23. Neuroscience and Ageing Research Unit, Institute for Advanced Medical Research and Training, College of Medicine, University of Ibadan , Ibadan , Nigeria

24. Center for Genomic and Precision Medicine, College of Medicine, University of Ibadan , Ibadan , Nigeria

25. Weill Institute for Neurosciences, University of California San Francisco , San Francisco, CA , USA

26. Lebanese American University , Beirut , Lebanon

Abstract

Abstract Introduction Non-cigarette tobacco (NCT) represents a form of tobacco use with a misperceived significance in chronic disease events. Whether NCT use is sufficient to promote stroke events, especially among Africans, is yet to be understood. This study assessed the relationship between NCT use and stroke among indigenous Africans. Methods A total of 7617 respondents (NCT users: 41 vs. non-NCT: 7576) from the Stroke Investigative Research and Educational Network (SIREN) study were included in the current analysis. NCT use was defined as self-reported use of smoked (cigars or piper) or smokeless (snuff or chewed) tobacco in the past year preceding stroke events. Stroke was defined based on clinical presentation and confirmed with a cranial computed tomography/magnetic resonance imaging. Multivariable-adjusted logistic regression was applied to estimate the odds ratio (OR) and 95% confidence interval (CI) for the relationship of NCT with stroke at a two-sided p < .05. Results Out of the 41 (0.54%) who reported NCT use, 27 (65.9%) reported using smokeless NCT. NCT users were older than non-NCT users (62.8 ± 15.7 vs. 57.7 ± 14.8 years). Overall, NCT use was associated with first-ever stroke (OR: 2.08; 95% CI: 1.02, 4.23) in the entire sample. Notably, smokeless NCT use was independently associated with higher odds of stroke (OR: 2.74; 95% CI: 1.15, 6.54), but smoked NCT use (OR: 0.16; 95% CI: 0.02, 1.63) presented a statistically insignificant association after adjusting for hypertension and other covariates. Conclusions NCT use was associated with higher odds of stroke, and public health interventions targeting NCT use might be promising in reducing the burden of stroke among indigenous Africans. Implications A detailed understanding of the relationship between NCT use and stroke will likely inform well-articulated policy guidance and evidence-based recommendations for public health prevention and management of stroke on the African continent.

Funder

SIREN

SIBS Genomics

African Neurobiobank for Precision Stroke Medicine ELSI project

ARISES

CaNVAS

sub-Saharan Africa Conference on Stroke

Training Africans to Lead and Execute Neurological Trials & Studies

National Research Foundation of Korea

Publisher

Oxford University Press (OUP)

Subject