ON RADIATION-INDUCED AGING: ACCELERATED OR PREMATURE AGING-Reference-Cited by-同舟云学术

ON RADIATION-INDUCED AGING: ACCELERATED OR PREMATURE AGING

Published:2022-09 Issue:13-15 Volume:198 Page:1155-1159
ISSN:0144-8420
Container-title:Radiation Protection Dosimetry
language:en
Short-container-title:

Author:

Wada Takahiro¹^ORCID,Kinugawa Tetsuhiro²^ORCID,Tanaka Satoshi³

Affiliation:

1. Kansai University Department of Pure and Applied Physics, , 3-3-35 Yamate-cho, Suita 564-8680, Japan

2. Osaka University Division of Sustainable Energy and Environmental Engineering, School of Engineering, , 2-1 Yamada-oka, Suita 565-0871, Japan

3. Institute for Environmental Sciences Department of Radiobiology, , 1-7 Ienomae, Rokkasho 039-3212, Japan

Abstract

Abstract The concept of radiation-induced aging is revisited from the viewpoint of a mathematical model. The effect of radiation on carcinogenesis is treated based on the Armitage–Doll multi-stage theory. The formula obtained for cancer incidence rate indicates that radiation dose can be explained in terms of time. Radiation-induced aging for acute and chronic exposures is described using age-specific cancer incidence rates as a measure of aging. It shows that accelerated aging is related to the dose rate, whereas premature aging is related to the cumulative dose, providing a simple and natural interpretation of radiation-induced aging. The usefulness of this approach is demonstrated by applying the formula to cancer prevalence data from mice chronically exposed to low dose-rate radiation.

Publisher

Oxford University Press (OUP)

Subject

Public Health, Environmental and Occupational Health,Radiology, Nuclear Medicine and imaging,General Medicine,Radiation,Radiological and Ultrasound Technology

Link

https://academic.oup.com/rpd/article-pdf/198/13-15/1155/45753610/ncac086.pdf

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4. Radiation-induced life-shortening and premature aging;Walburg;Adv. Radiat. Biol.,1975

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