DOSE-RATE EFFECT OF RADIATION ON RAT MAMMARY CARCINOGENESIS AND AN EMERGING ROLE FOR STEM CELL BIOLOGY-Reference-Cited by-同舟云学术

DOSE-RATE EFFECT OF RADIATION ON RAT MAMMARY CARCINOGENESIS AND AN EMERGING ROLE FOR STEM CELL BIOLOGY

Published:2022-09 Issue:13-15 Volume:198 Page:1036-1046
ISSN:0144-8420
Container-title:Radiation Protection Dosimetry
language:en
Short-container-title:

Author:

Imaoka Tatsuhiko¹^ORCID,Nishimura Mayumi¹,Daino Kazuhiro¹^ORCID,Hosoki Ayaka¹,Kudo Ken-ichi¹²^ORCID,Iizuka Daisuke¹,Nagata Kento¹,Takabatake Masaru¹³,Nishimura Yukiko¹,Kokubo Toshiaki⁴,Morioka Takamitsu¹^ORCID,Doi Kazutaka⁵,Shimada Yoshiya¹⁶,Kakinuma Shizuko¹^ORCID

Affiliation:

1. National Institute of Radiological Sciences, National Institutes for Quantum Science and Technology Department of Radiation Effects Research, , Chiba 263-8555, Japan

2. School of Medicine, Fukushima Medical University Department of Radiation Life Sciences, , Fukushima 960-1247, Japan

3. Graduate School of Human Health Sciences, Tokyo Metropolitan University Department of Radiological Sciences, , Tokyo 116-8551, Japan

4. National Institutes for Quantum Science and Technology Laboratory Animal and Genome Sciences Section, , Chiba 263-8555, Japan

5. National Institute of Radiological Sciences, National Institutes for Quantum Science and Technology Department of Radiation Regulatory Science Research, , Chiba 263-8555, Japan

6. Institute for Environmental Sciences , Aomori 039-3212, Japan

Abstract

Abstract The uncertain cancer risk of protracted radiation exposure at low dose rates is an important issue in radiological protection. Tissue stem/progenitor cells are a supposed origin of cancer and may contribute to the dose-rate effect on carcinogenesis. The authors have shown that female rats subjected to continuous whole body γ irradiation as juveniles or young adults have a notably reduced incidence of mammary cancer as compared with those irradiated acutely. Experiments using the mammosphere formation assay suggested the presence of radioresistant progenitor cells. Cell sorting indicated that basal progenitor cells in rat mammary gland were more resistant than luminal progenitors to killing by acute radiation, especially at high doses. Thus, the evidence indicates a cell-type-dependent inactivation of mammary cells that manifests only at high acute doses, implying a link to the observed dose-rate effect on carcinogenesis.

Funder

Japan Society for the Promotion of Science KAKENHI

Publisher

Oxford University Press (OUP)

Subject

Public Health, Environmental and Occupational Health,Radiology, Nuclear Medicine and imaging,General Medicine,Radiation,Radiological and Ultrasound Technology

Link

https://academic.oup.com/rpd/article-pdf/198/13-15/1036/45754344/ncac050.pdf

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