A national survey on prevalence of possible echocardiographic red flags of amyloid cardiomyopathy in consecutive patients undergoing routine echocardiography: study design and patients characterization—the first insight from the AC-TIVE Study

Author:

Merlo Marco1ORCID,Porcari Aldostefano1ORCID,Pagura Linda1,Cameli Matteo2ORCID,Vergaro Giuseppe3,Musumeci Beatrice4ORCID,Biagini Elena5ORCID,Canepa Marco67ORCID,Crotti Lia89ORCID,Imazio Massimo10ORCID,Forleo Cinzia11,Cappelli Francesco12ORCID,Favale Stefano11,Di Bella Gianluca13,Dore Franca14,Lombardi Carlo Mario15,Pavasini Rita16,Rella Valeria8,Palmiero Giuseppe17,Caiazza Martina17,Albanese Miriam11,Guaricci Andrea Igoren11,Branzi Giovanna8,Caponetti Angelo Giuseppe5,Saturi Giulia5,La Malfa Giovanni6,Merlo Andrea Carlo6,Andreis Alessandro10,Bruno Francesco10ORCID,Longo Francesca1,Sfriso Enrico1,Di Ienno Luca16,De Carli Giuseppe2,Giacomin Elisa2,Spini Valentina3,Milidoni Antonino15,Limongelli Giuseppe17ORCID,Autore Camillo4,Olivotto Iacopo12ORCID,Badano Luigi89,Parati Gianfranco89ORCID,Perlini Stefano1819ORCID,Metra Marco15ORCID,Emdin Michele3ORCID,Rapezzi Claudio2021ORCID,Sinagra Gianfranco1ORCID

Affiliation:

1. Cardiovascular Department, Center for Diagnosis and Treatment of Cardiomyopathies, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI) and University of Trieste, Via Valdoni 1, 34149 Trieste, Italy

2. Division of Cardiology, Department of Medical Biotechnologies, University of Siena, Viale Mario Bracci 16, 53100, Siena, Italy

3. Division of Cardiology and Cardiovascular Medicine, Fondazione Toscana Gabriele Monasterio and Istituto di Scienze della Vita, Scuola Superiore Sant’Anna, Via Giuseppe Moruzzi 1, 56124, Pisa, Italy

4. Department of Clinical and Molecular Medicine, Faculty of Medicine and Psychology, Sapienza University, Via di Grottarossa 1035-39, 00189, Rome, Italy

5. Department of Experimental, Diagnostic and Specialty Medicine, Cardiology Unit, IRCCS, University Sant’Orsola Hospital, University of Bologna, Via Massarenti 9, 40138, Bologna, Italy

6. Department of Internal Medicine, Cardiovascular Unit, University of Genova, Viale Benedetto XV 10, 16132, Genova, Italy

7. Ospedale Policlinico San Martino IRCCS, Largo Rosanna Benzi 10, 16132, Genova, Italy

8. Department of Cardiovascular, Neural and Metabolic Sciences, Cardiomyopathy Unit, Istituto Auxologico Italiano, Piazzale Brescia, 20, 20149, Milan, Italy

9. Department of Medicine and Surgery, University Milano, Bicocca, Piazza dell'Ateneo Nuovo 1, 20126, Milan, Italy

10. Division of Cardiology, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, University of Turin, Corso Bramante 88, 10126, Turin, Italy

11. Department of Emergency and Organ Transplantation, Cardiology Unit, University of Bari Aldo Moro, Piazza Giulio Cesare 11, 70124, Bari, Italy

12. Cardiomyopathy Unit, Careggi University Hospital, University of Florence, Largo Brambilla 3, 50134, Florence, Italy

13. Department of Cardiology, University of Messina, Via Consolare Valeria 1, 98125, Messina, Italy

14. Department of Nuclear Medicine, Azienda Sanitaria Universitaria Giuliano-Isontina (ASUGI) and University of Trieste, Strada di Fiume 447, 34129, Trieste, Italy

15. Cardiology, Department of Medical and Surgical Specialities, Radiological Sciences and Public Health, University of Brescia, Piazzale Spedali Civili 1, 25123, Brescia, Italy

16. Cardiology Unit, Azienda Ospedaliero Universitaria di Ferrara, Cona, Via Aldo Moro 8, 44124, Ferrara, Italy

17. Department of Translational Medical Sciences, Inherited and Rare Heart Disease, Vanvitelli Cardiology, University of Campania Luigi Vanvitelli, Piazza Luigi Miraglia 2, 80138, Napoli, Italy

18. Emergency Department and Amyloid Research and Treatment Center, IRCCS Policlinico San Matteo Foundation, Viale Camillo Golgi 19, 27100, Pavia, Italy

19. Department of Internal Medicine, University of Pavia, Via Aselli 43/45, 27100, Pavia, Italy

20. Cardiovascular Center, University of Ferrara, Via Savonarola 9, 44121, Ferrara, Italy

21. Maria Cecilia Hospital, GVM Care & Research, Via Corriera, 1, 48033, Cotignola, Italy

Funder

Pfizer

Publisher

Oxford University Press (OUP)

Subject

Cardiology and Cardiovascular Medicine,Epidemiology

Reference10 articles.

1. Expert consensus recommendations for the suspicion and diagnosis of transthyretin cardiac amyloidosis;Maurer;Circ Hear Fail,2019

2. Transthyretin amyloid cardiomyopathy: an uncharted territory awaiting discovery;Porcari;Eur J Intern Med,2020

3. Multiparametric echocardiography scores for the diagnosis of cardiac amyloidosis;Boldrini;JACC Cardiovasc Imaging,2020

4. Addressing common questions encountered in the diagnosis and management of cardiac amyloidosis;Maurer;Circulation,2017

5. Clinically significant cardiac amyloidosis. Clinicopathologic findings in 15 patients;Buja;Am J Cardiol,1970

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