Genetically predicted gestational age and birth weight are associated with cardiac and pulmonary vascular remodelling in adulthood

Author:

Schuermans Art123ORCID,Ardissino Maddalena45ORCID,Nauffal Victor16ORCID,Khurshid Shaan127,Pirruccello James P18,Ellinor Patrick T127ORCID,Lewandowski Adam J9,Natarajan Pradeep1210ORCID,Honigberg Michael C1210ORCID

Affiliation:

1. Cardiovascular Disease Initiative and Program in Medical and Population Genetics, Broad Institute of Harvard and MIT , Cambridge, MA , USA

2. Cardiovascular Research Center and Center for Genomic Medicine, Massachusetts General Hospital , Boston, MA , USA

3. Department of Cardiovascular Sciences, KU Leuven , Leuven , Belgium

4. National Heart and Lung Institute, Imperial College London , London , UK

5. Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge , Cambridge , UK

6. Cardiovascular Division, Brigham and Women’s Hospital , Boston, MA , USA

7. Demoulas Center for Cardiac Arrhythmias, Massachusetts General Hospital , Boston, MA , USA

8. Division of Cardiology and Institute for Human Genetics, University of California San Francisco , San Francisco, CA , USA

9. Oxford Cardiovascular Clinical Research Facility, Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford , Oxford , UK

10. Division of Cardiology, Massachusetts General Hospital , 185 Cambridge St. CPZN 3.187, Boston, 02114 MA , USA

Funder

Belgian American Educational Foundation

National Institutes of Health

Hassenfeld Scholar Award

Paul & Phyllis Fireman Endowed Chair in Vascular Medicine

Massachusetts General Hospital

U.S. National Heart, Lung, and Blood Institute

National Institute of Diabetes and Digestive and Kidney Diseases

Fondation Leducq

American Heart Association

Publisher

Oxford University Press (OUP)

Subject

Cardiology and Cardiovascular Medicine,Epidemiology

Reference10 articles.

1. Early pulmonary vascular disease in young adults born preterm;Goss;Am J Respir Crit Care Med,2018

2. Exercise capacity in young adults born small for gestational age;Crispi;JAMA Cardiol,2021

3. Changes in the preterm heart from birth to young adulthood: a meta-analysis;Telles;Pediatrics,2020

4. New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism;Horikoshi;Nat Genet,2012

5. Variants in the fetal genome near pro-inflammatory cytokine genes on 2q13 associate with gestational duration;Liu;Nat Commun,2019

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