Use of new paediatric VO2max reference equations to evaluate aerobic fitness in overweight or obese children with congenital heart disease

Author:

Amedro Pascal12ORCID,Mura Thibault34ORCID,Matecki Stefan56ORCID,Guillaumont Sophie57ORCID,Requirand Anne5,Jeandel Claire8,Kollen Laura9ORCID,Gavotto Arthur610ORCID

Affiliation:

1. Paediatric and Congenital Cardiology Department, M3C National Reference Centre, Bordeaux University Hospital , Bordeaux , France

2. IHU Liryc, Electrophysiology and Heart Modelling Institute, INSERM 1045, Bordeaux University Foundation , Pessac , France

3. INSERM, U1061, Neuropsychiatry: Epidemiological and Clinical Research, University of Montpellier , 39 Av. Charles Flahault, 34090, Montpellier , France

4. Department of Biostatistics, Clinical Epidemiology, Public Health, and Innovation in Methodology, Nimes University Hospital, University of Montpellier , Place du Professeur Debré, 30029, Nimes , France

5. Paediatric and Congenital Cardiology Department, M3C Regional Reference CHD Centre, Montpellier University Hospital , Montpellier , France

6. PhyMedExp, CNRS, INSERM, University of Montpellier , 371 Avenue du Doyen Giraud, 34295, Montpellier, France

7. Paediatric Cardiology and Rehabilitation Unit, St-Pierre Institute , Palavas-Les-Flots , France

8. Paediatric Endocrine Unit, Department of Paediatrics, Hôpital A. de Villeneuve, CHU Montpellier , Montpellier Cedex 34295 , France

9. Department of Paediatric gastroenterology, Montpellier University Hospital , Montpellier , France

10. Department of Neonatal Medicine and Paediatric Intensive Care, Arnaud de Villeneuve Hospital, Montpellier University Hospital Centre, University of Montpellier , 371 Avenue du Doyen Giraud, Montpellier 34295 , France

Abstract

Abstract Aims Overweight and obesity in children with congenital heart disease (CHD) represent an alarming cardiovascular risk. Promotion of physical activity and cardiac rehabilitation in this population requires assessing the level of aerobic fitness (VO2max) by a cardiopulmonary exercise test (CPET). Nevertheless, the interpretation of CPET in overweight/obese children with CHD remains challenging as VO2max is affected by both the cardiac condition and the body mass index (BMI). The new paediatric VO2max  Z-score reference equations, based on a logarithmic function of VO2max, height and BMI, were applied to overweight/obese children with a CHD and compared with overweight/obese children without any other chronic condition. Methods and results In this cross-sectional controlled study, 344 children with a BMI > 85th percentile underwent a CPET (54% boys; mean age 11.5 ± 3.1 years; 100 CHD; 244 controls). Using the VO2max  Z-score equations, aerobic fitness was significantly lower in obese/overweight CHD children than that in matched obese/overweight control children (−0.43 ± 1.27 vs. −0.01 ± 1.09; P = 0.02, respectively), and the proportion of children with impaired aerobic fitness was significantly more important in obese/overweight CHD children than in matched controls (17% vs.6%, P = 0.02, respectively). The paediatric VO2max  Z-score reference equations also identified specific complex CHD at risk of aerobic fitness impairment (univentricular heart and right outflow tract anomalies). Using Cooper’s weight- and height-based linear equations, similar matched-comparisons analyses found no significant group differences. Conclusions As opposed to the existing linear models, the new paediatric VO2max  Z-score equations can discriminate the aerobic fitness of obese/overweight children with CHD from that of obese/overweight children without any chronic disease. Registration ClinicalTrials.gov NCT04815577.

Funder

Department of Paediatrics of Montpellier University Hospital

Publisher

Oxford University Press (OUP)

Subject

Cardiology and Cardiovascular Medicine,Epidemiology

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3