Impact of anthropometric factors on outcomes in atrial fibrillation patients: analysis on 10 220 patients from the European Society of Cardiology (ESC)-European Heart Rhythm Association (EHRA) EurObservational Research Programme on Atrial Fibrillation (EORP-AF) general long-term registry-Reference-Cited by-同舟云学术

Impact of anthropometric factors on outcomes in atrial fibrillation patients: analysis on 10 220 patients from the European Society of Cardiology (ESC)-European Heart Rhythm Association (EHRA) EurObservational Research Programme on Atrial Fibrillation (EORP-AF) general long-term registry

Published:2022-06-07 Issue:15 Volume:29 Page:1967-1981
ISSN:2047-4873
Container-title:European Journal of Preventive Cardiology
language:en
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Author:

Boriani Giuseppe¹^ORCID,Vitolo Marco¹²³,Malavasi Vincenzo L¹,Proietti Marco²⁴⁵^ORCID,Fantecchi Elisa¹,Diemberger Igor⁶^ORCID,Fauchier Laurent⁷^ORCID,Marin Francisco⁸,Nabauer Michael⁹^ORCID,Potpara Tatjana S¹⁰¹¹,Dan Gheorghe-Andrei¹²,Kalarus Zbigniew¹³,Tavazzi Luigi¹⁴,Maggioni Aldo Pietro¹⁵,Lane Deirdre A²¹⁶,Lip Gregory Y H²¹⁶,Boriani G,Lip G Y H,Tavazzi L,Maggioni A P,Dan G-A,Potpara T,Nabauer M,Marin F,Kalarus Z,Fauchier L,Goda A,Mairesse G,Shalganov T,Antoniades L,Taborsky M,Riahi S,Muda P,García Bolao I,Piot O,Nabauer M,Etsadashvili K,Simantirakis EN,Haim M,Azhari A,Santini M,Mirrakhimov E,Kulzida K,Erglis A,Poposka L,Burg MR,Crijns H,Atar D,Lenarczyk R,Martins Oliveira M,Shah D,Dan G-A,Serdechnaya E,Potpara T,Diker E,Lip G Y H,Lane D,Zëra E,Ekmekçiu U,Paparisto V,Tase M,Gjergo H,Dragoti J,Goda A,Ciutea M,Ahadi N,el Husseini Z,Raepers M,Leroy J,Haushan P,Jourdan A,Lepiece C,Desteghe L,Vijgen J,Koopman P,Van Genechten G,Heidbuchel H,Boussy T,De Coninck M,Van Eeckhoutte H,Bouckaert N,Friart A,Boreux J,Arend C,Evrard P,Stefan L,Hoffer E,Herzet J,Massoz M,Celentano C,Sprynger M,Pierard L,Melon P,Van Hauwaert B,Kuppens C,Faes D,Van Lier D,Van Dorpe A,Gerardy A,Deceuninck O,Xhaet O,Dormal F,Ballant E,Blommaert D,Yakova D,Hristov M,Yncheva T,Stancheva N,Tisheva S,Tokmakova M,Nikolov F,Gencheva D,Shalganov T,Kunev B,Stoyanov M,Marchov D,Gelev V,Traykov V,Kisheva A,Tsvyatkov H,Shtereva R,Bakalska-Georgieva S,Slavcheva S,Yotov Y,Kubíčková M,Marni Joensen A,Gammelmark A,Hvilsted Rasmussen L,Dinesen P,Riahi S,Krogh Venø S,Sorensen B,Korsgaard A,Andersen K,Fragtrup Hellum C,Svenningsen A,Nyvad O,Wiggers P,May O,Aarup A,Graversen B,Jensen L,Andersen M,Svejgaard M,Vester S,Hansen S,Lynggaard V,Ciudad M,Vettus R,Muda P,Maestre A,Castaño S,Cheggour S,Poulard J,Mouquet V,Leparrée S,Bouet J,Taieb J,Doucy A,Duquenne H,Furber A,Dupuis J,Rautureau J,Font M,Damiano P,Lacrimini M,Abalea J,Boismal S,Menez T,Mansourati J,Range G,Gorka H,Laure C,Vassalière C,Elbaz N,Lellouche N,Djouadi K,Roubille F,Dietz D,Davy J,Granier M,Winum P,Leperchois-Jacquey C,Kassim H,Marijon E,Le Heuzey J,Fedida J,Maupain C,Himbert C,Gandjbakhch E,Hidden-Lucet F,Duthoit G,Badenco N,Chastre T,Waintraub X,Oudihat M,Lacoste J,Stephan C,Bader H,Delarche N,Giry L,Arnaud D,Lopez C,Boury F,Brunello I,Lefèvre M,Mingam R,Haissaguerre M,Le Bidan M,Pavin D,Le Moal V,Leclercq C,Piot O,Beitar T,Martel I,Schmid A,Sadki N,Romeyer-Bouchard C,Da Costa A,Arnault I,Boyer M,Piat C,Fauchier L,Lozance N,Nastevska S,Doneva A,Fortomaroska Milevska B,Sheshoski B,Petroska K,Taneska N,Bakrecheski N,Lazarovska K,Jovevska S,Ristovski V,Antovski A,Lazarova E,Kotlar I,Taleski J,Poposka L,Kedev S,Zlatanovik N,Jordanova S,Bajraktarova Proseva T,Doncovska S,Maisuradze D,Esakia A,Sagirashvili E,Lartsuliani K,Natelashvili N,Gumberidze N,Gvenetadze R,Etsadashvili K,Gotonelia N,Kuridze N,Papiashvili G,Menabde I,Glöggler S,Napp A,Lebherz C,Romero H,Schmitz K,Berger M,Zink M,Köster S,Sachse J,Vonderhagen E,Soiron G,Mischke 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Affiliation:

1. Cardiology Division, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Policlinico di Modena , Modena , Italy

2. Liverpool Centre for Cardiovascular Science, University of Liverpool and Liverpool Heart & Chest Hospital , Liverpool , UK

3. Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia , Modena , Italy

4. Department of Clinical Sciences and Community Health, University of Milan , Milan , Italy

5. Geriatric Unit, IRCCS Istituti Clinici Scientifici Maugeri , Milan , Italy

6. Department of Experimental, Diagnostic and Specialty Medicine, Institute of Cardiology, University of Bologna, Policlinico S. Orsola-Malpighi , Bologna , Italy

7. Service de Cardiologie, Centre Hospitalier Universitaire Trousseau , Tours , France

8. Department of Cardiology, Hospital Universitario Virgen de la Arrixaca, IMIB-Arrixaca, University of Murcia, CIBERCV , Murcia , Spain

9. Department of Cardiology, Ludwig-Maximilians-University , Munich , Germany

10. School of Medicine, University of Belgrade , Belgrade , Serbia

11. Intensive Arrhythmia Care, Cardiology Clinic, Clinical Center of Serbia , Belgrade , Serbia

12. ‘Carol Davila’ University of Medicine, Colentina University Hospital , Bucharest , Romania

13. Department of Cardiology, SMDZ in Zabrze, Medical University of Silesia, Katowice, Silesian Centre for Heart Diseases , Zabrze , Poland

14. Maria Cecilia Hospital, GVM Care & Research , Cotignola , Italy

15. ANMCO Research Center , Firenze , Italy

16. Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Aalborg University , Aalborg , Denmark

Abstract

Abstract Aim To investigate the association of anthropometric parameters [height, weight, body mass index (BMI), body surface area (BSA), and lean body mass (LBM)] with outcomes in atrial fibrillation (AF). Methods and results Ten-thousand two-hundred twenty patients were enrolled [40.3% females, median age 70 (62–77) years, followed for 728 (interquartile range 653–745) days]. Sex-specific tertiles were considered for the five anthropometric variables. At the end of follow-up, survival free from all-cause death was worse in the lowest tertiles for all the anthropometric variables analyzed. On multivariable Cox regression analysis, an independent association with all-cause death was found for the lowest vs. middle tertile when body weight (hazard ratio [HR] 1.66, 95%CI 1.23–2.23), BMI (HR 1.65, 95%CI 1.23–2.21), and BSA (HR 1.49, 95%CI 1.11–2.01) were analysed in female sex, as well as for body weight in male patients (HR 1.61, 95%CI 1.25–2.07). Conversely, the risk of MACE was lower for the highest tertile (vs. middle tertile) of BSA and LBM in males and for the highest tertile of weight and BSA in female patients. A higher occurrence of haemorrhagic events was found for female patients in the lowest tertile of height [odds ratio (OR) 1.90, 95%CI 1.23–2.94] and LBM (OR 2.13, 95%CI 1.40–3.26). Conclusions In AF patients height, weight, BMI, BSA, and LBM were associated with clinical outcomes, with all-cause death being higher for patients presenting lower values of these variables, i.e. in the lowest tertiles of distribution. The anthropometric variables independently associated with other outcomes were also different between male and female subjects.

Funder

Sanofi

Vifor

Publisher

Oxford University Press (OUP)

Subject

Cardiology and Cardiovascular Medicine,Epidemiology

Link

https://academic.oup.com/eurjpc/advance-article-pdf/doi/10.1093/eurjpc/zwac115/44145697/zwac115.pdf

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