Affiliation:
1. Department of Epidemiology, Erasmus University Medical Center, Doctor Molewaterplein 40, 3015 GD Rotterdam, the Netherlands
Abstract
Abstract
Aims
Data on the lifetime risk of type 2 diabetes (T2D) incidence across different cardiovascular health (CVH) categories are scarce. Moreover, it remains unclear whether a genetic predisposition modifies this association.
Methods and results
Using data from the prospective population-based Rotterdam Study, a CVH score (body mass index, blood pressure, total cholesterol, smoking status, diet, and physical activity) was calculated and further categorized at baseline. Genetic predisposition to T2D was assessed and divided into tertiles by creating a genetic risk score (GRS). We estimated the lifetime risk for T2D within different CVH and GRS categories. Among 5993 individuals free of T2D at baseline [mean (standard deviation) age, 69.1 (8.5) years; 58% female], 869 individuals developed T2D during follow-up. At age 55 years, the remaining lifetime risk of T2D was 22.6% (95% CI: 19.4–25.8) for ideal, 28.3% (25.8–30.8) for intermediate, and 32.6% (29.0–36.2) for poor CVH. After further stratification by GRS tertiles, the lifetime risk for T2D was still the lowest for ideal CVH in the lowest GRS tertiles [21.5% (13.7–29.3)], in the second GRS tertile [20.8% (15.9–25.8)], and in the highest tertile [23.5% (18.5–28.6)] when compared with poor and intermediate CVH.
Conclusion
Our results highlight the importance of favourable CVH in preventing T2D among middle-aged individuals regardless of their genetic predisposition.
Funder
Erasmus University Rotterdam; Netherlands Organization for Scientific Research
Netherlands Organization for Health Research and Development
Research Institute for Diseases in the Elderly
Netherlands Genomics Initiative
Netherlands Ministry of Education, Culture and Science
Netherlands Ministry of Health, Welfare and Sports
European Commission; and Municipality of Rotterdam
ZonMw VENI
Innovative Medicine Initiative 2 Joint Undertaking
European Union’s Horizon 2020 research and innovation programme and EFPIA and T1D Exchange
Obesity Action Coalition
China Scholarship Council
Publisher
Oxford University Press (OUP)
Subject
Cardiology and Cardiovascular Medicine,Epidemiology
Cited by
12 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献