1. Unit of Cardiovascular Medicine, Department of Medicine, Karolinska Institutet , Stockholm , Sweden
2. MRC Clinical Trials Unit, University College of London , London , UK
3. Section of Pharmacology, Catholic University School of Medicine , Largo Francesco Vito 1, 00168 Rome , Italy
4. Department NeuroFarBa, University of Florence , Viale Gaetano Pieraccini 6, 50139 Florence , Italy