Reversion of cardiac dysfunction by a novel orally available calcium/calmodulin-dependent protein kinase II inhibitor, RA306, in a genetic model of dilated cardiomyopathy

Author:

Beauverger Philippe1,Ozoux Marie-Laure1,Bégis Guillaume2,Glénat Valérie3,Briand Véronique1,Philippo Marie-Claire1,Daveu Cyril1,Tavares Georges1,Roy Sébastien3,Corbier Alain1,Briand Pascale1,Dorchies Olivier4,Bauchet Anne-Laure5,Nicolai Eric2,Duclos Olivier2,Tamarelle Dorothée6,Pruniaux Marie-Pierre1,Muslin Anthony J7,Janiak Philip1ORCID

Affiliation:

1. Cardiovascular&Metabolism Therapeutic Area, Sanofi R&D, 1 avenue Pierre Brossolette, Chilly-Mazarin, France

2. Integrated Drug Discovery platform, Sanofi R&D, 1 avenue Pierre Brossolette, Chilly-Mazarin, France

3. Integrated Drug Discovery platform, Sanofi R&D, 13 quai Jules Guesde, Vitry-sur-Seine Cedex, France

4. Preclinical Safety platform, Sanofi R&D, 13 quai Jules Guesde, Vitry-sur-Seine Cedex, France

5. Translational Medicine and Early Development platform, Sanofi R&D, 13 quai Jules Guesde, Vitry-sur-Seine Cedex, France

6. Biostatistics and Programming platform, Sanofi R&D, 13 quai Jules Guesde, Vitry-sur-Seine Cedex, France

7. Cardiovascular&Metabolism Therapeutic Area, Sanofi R&D, 640 Memorial Drive, MA, Cambridge, USA

Funder

Sanofi

Publisher

Oxford University Press (OUP)

Subject

Physiology (medical),Cardiology and Cardiovascular Medicine,Physiology

Reference48 articles.

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2. 2009 focused update: ACCF/AHA guidelines for the diagnosis and management of heart failure in adults: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines: developed in collaboration with the International Society for Heart and Lung Transplantation;Jessup;Circulation,2009

3. guideline update for the diagnosis and management of chronic heart failure in the adult: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Update the 2001 Guidelines for the Evaluation and Management of Heart Failure): developed in collaboration with the American College of Chest Physicians and the International Society for Heart and Lung Transplantation: endorsed by the Heart Rhythm Society;Hunt;Circulation,2005

4. Structure-function of the multifunctional Ca2+/calmodulin-dependent protein kinase II;Hudmon;Biochem J,2002

5. Impaired spatial learning in alpha-calcium-calmodulin kinase II mutant mice;Silva;Science,1992

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