Three laws of teleonometrics

Abstract

Abstract We define teleonometrics as the theoretical and empirical study of teleonomy. We propose three laws for teleonometrics. The first law describes the hierarchical organization of teleonomic functions across biological levels from genes to individuals. According to this law, the number of goal-directed functions increases from individuals (one goal, maximizing inclusive fitness) to intermediate levels and to genes and alleles (myriad time-, space- and context-dependent goals, depending upon degrees and patterns of pleiotropy). The second law describes the operation of teleonomic functions under trade-offs, coadaptations and negative and positive pleiotropies, which are universal in biological systems. According to this law, the functions of an allele, gene or trait are described and defined by patterns of antagonistic (trading off) and compatible (coadapted) functions. The third law of teleonometrics is that the major transitions in evolution are driven by the origins of novel, emergent goals associated with functional changes and by the breaking and reshaping of trade-offs, especially by mechanisms involving increases in resources or time, and new divisions of labour or function. We illustrate the application of these laws using data from three empirical vignettes, which help to show the usefulness of teleonometric viewpoints for understanding the interfaces between function, trade-offs and dysfunctions manifest as disease.