NYX-2925 Is a Novel NMDA Receptor-Specific Spirocyclic-β-Lactam That Modulates Synaptic Plasticity Processes Associated with Learning and Memory-Reference-Cited by-同舟云学术

NYX-2925 Is a Novel NMDA Receptor-Specific Spirocyclic-β-Lactam That Modulates Synaptic Plasticity Processes Associated with Learning and Memory

Published:2017-11-01 Issue:3 Volume:21 Page:242-254
ISSN:1461-1457
Container-title:International Journal of Neuropsychopharmacology
language:en
Short-container-title:

Author:

Khan M Amin¹,Houck David R¹,Gross Amanda L¹,Zhang Xiao-lei²,Cearley Cassia¹,Madsen Torsten M¹,Kroes Roger A¹³,Stanton Patric K²,Burgdorf Jeffrey¹³,Moskal Joseph R¹³

Affiliation:

1. Aptinyx Inc., Evanston, Ilinois

2. Department of Cell Biology & Anatomy, New York Medical College, Valhalla, New York

3. Falk Center for Molecular Therapeutics, Department of Biomedical Engineering, Northwestern University, Evanston, Ilinois

Publisher

Oxford University Press (OUP)

Subject

Pharmacology (medical),Psychiatry and Mental health,Pharmacology

Link

http://academic.oup.com/ijnp/article-pdf/21/3/242/24250386/pyx096.pdf

Reference62 articles.

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3. Differential roles of NR2A and NR2B-containing NMDA receptors in LTP and LTD in the CA1 region of two-week old rat hippocampus;Bartlett;Neuropharmacology,2007

4. Chirospecific synthesis of spirocyclic beta-lactams and their characterization as potent type II beta-turn inducing peptide mimetics;Bittermann;J Org Chem,2006

5. A synaptic model of memory: long-term potentiation in the hippocampus;Bliss;Nature,1993

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