Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport

Author:

Butler Victoria J1,Salazar Dominique A1,Soriano-Castell David2,Alves-Ferreira Miguel2345,Dennissen Frank J A678,Vohra Mihir9,Oses-Prieto Juan A10,Li Kathy H10,Wang Austin L1,Jing Beibei1,Li Biao11,Groisman Alex12,Gutierrez Edgar12,Mooney Sean11,Burlingame Alma L10,Ashrafi Kaveh9,Mandelkow Eva-Maria678,Encalada Sandra E2,Kao Aimee W1

Affiliation:

1. Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, CA, USA

2. Departments of Molecular Medicine and Molecular and Cellular Neuroscience, Dorris Neuroscience Center, The Scripps Research Institute, La Jolla, CA, USA

3. Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal

4. Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal

5. Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Porto, Portugal

6. German Center for Neurodegenerative Diseases (DZNE), Ludwig-Erhard-Allee 2, Bonn, Germany

7. MPI for Neurological Research, Hamburg Outstation, c/o Deutsches Elektronen-Synchrotron, Notkestrasse 85, Hamburg, Germany

8. The Center of Advanced European Studies and Research, Ludwig-Erhard-Allee 2, Bonn, Germany

9. Department of Physiology, University of California San Francisco, San Francisco, CA, USA

10. Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, CA, USA

11. The Buck Institute for Research on Aging, Novato, CA, USA

12. Department of Physics, University of California San Diego, La Jolla, CA, USA

Funder

Howard Hughes Medical Institute

National Institutes of Health

National Institute of General Medical Sciences

FCT fellowship

Arlene and Arnold Goldstein

Glenn Foundation for Medical Research

The Baxter Foundation

Ellison Medical Foundation

Hillblom Foundation Graduate Student Fellowship

Glenn/AFAR Aging Research Scholarship

National Institute on Aging

Paul G. Allen Family Foundation

American Federation for Aging Research

Rainwater Tau Consortium

Publisher

Oxford University Press (OUP)

Subject

Genetics(clinical),Genetics,Molecular Biology,General Medicine

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