1. Department of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli—IRCCS , Largo A. Gemelli 8, Rome 00168 , Italy
2. Department of Cardiovascular and Pulmonary Sciences, Catholic University School of Medicine , Largo F. Vito 1, Rome 00168 , Italy
3. Center of Excellence on Ageing, CAST, ‘G. d’Annunzio’ University School of Medicine , Chieti , Italy