Translational opportunities of single-cell biology in atherosclerosis-Reference-Cited by-同舟云学术

Translational opportunities of single-cell biology in atherosclerosis

Published:2022-12-07 Issue:14 Volume:44 Page:1216-1230
ISSN:0195-668X
Container-title:European Heart Journal
language:en
Short-container-title:

Author:

de Winther Menno P J¹^ORCID,Bäck Magnus²³^ORCID,Evans Paul⁴^ORCID,Gomez Delphine⁵^ORCID,Goncalves Isabel⁶⁷^ORCID,Jørgensen Helle F⁸^ORCID,Koenen Rory R⁹^ORCID,Lutgens Esther¹⁰¹¹¹²^ORCID,Norata Giuseppe Danilo¹³¹⁴^ORCID,Osto Elena¹⁵^ORCID,Dib Lea¹⁶^ORCID,Simons Michael¹⁷^ORCID,Stellos Konstantinos¹⁸^ORCID,Ylä-Herttuala Seppo¹⁹^ORCID,Winkels Holger²⁰^ORCID,Bochaton-Piallat Marie-Luce²¹^ORCID,Monaco Claudia¹⁶^ORCID

Affiliation:

1. Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences, Amsterdam Infection and Immunity, Amsterdam UMC location University of Amsterdam , Meibergdreef 9, 1105AZ Amsterdam , The Netherlands

2. Translational Cardiology, Karolinska Institute and Karolinska University Hospital , Stockholm , Sweden

3. University of Lorraine, INSERM U1116, Nancy University Hospital , Nancy , France

4. Department of Infection, Immunity and Cardiovascular Disease, INSIGNEO Institute, and the Bateson Centre, University of Sheffield , Sheffield , UK

5. Department of Medicine, Division of Cardiology, Heart, Lung, Blood and Vascular Medicine Institute, University of Pittsburgh , Pittsburgh, PA , USA

6. Cardiovascular Research Translational Studies, Clinical Sciences, Lund University , Malmö , Sweden

7. Department of Cardiology, Skåne University Hospital , Malmö , Sweden

8. Cardiorespiratory Medicine Section, Department of Medicine, University of Cambridge , Hills Road, Cambridge CB2 0QQ , UK

9. Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University , Maastricht , The Netherlands

10. Institute of Cardiovascular Prevention (IPEK), Ludwig-Maximilian’s Universität , Munich , Germany

11. German Centre of Cardiovascular Research (DZHK), partner site Munich Heart Alliance , Munich , Germany

12. Cardiovascular Medicine, Experimental CardioVascular Immunology Laboratory, Mayo Clinic , Rochester, MN , USA

13. Department of Excellence in Pharmacological and Biomolecular Sciences, Università degli Studi di Milano , Milan , Italy

14. Center for the Study of Atherosclerosis, SISA, Bassini Hospital, Cinisello Balsamo , Milan , Italy

15. Institute of Clinical Chemistry and Department of Cardiology, Heart Center, University Hospital and University of Zurich , Zurich , Switzerland

16. Kennedy Institute of Rheumatology, NDORMS, University of Oxford , Roosevelt Drive, OX37FY Oxford , UK

17. Departments of Internal Medicine and Cell Biology, Yale University and Yale Cardiovascular Research Center , 300 George St, New Haven, CT 06511 , USA

18. European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University , Mannheim , Germany

19. A.I. Virtanen Institute, University of Eastern Finland and Heart Center, Kuopio University Hospital , Kuopio , Finland

20. Department of Internal Medicine III, Division of Cardiology, University of Cologne, Faculty of Medicine and University Hospital Cologne , Kerpener Str. 62, 50937 Cologne , Germany

21. Department of Pathology and Immunology, Faculty of Medicine, University of Geneva , Geneva , Switzerland

Abstract

Abstract The advent of single-cell biology opens a new chapter for understanding human biological processes and for diagnosing, monitoring, and treating disease. This revolution now reaches the field of cardiovascular disease (CVD). New technologies to interrogate CVD samples at single-cell resolution are allowing the identification of novel cell communities that are important in shaping disease development and direct towards new therapeutic strategies. These approaches have begun to revolutionize atherosclerosis pathology and redraw our understanding of disease development. This review discusses the state-of-the-art of single-cell analysis of atherosclerotic plaques, with a particular focus on human lesions, and presents the current resolution of cellular subpopulations and their heterogeneity and plasticity in relation to clinically relevant features. Opportunities and pitfalls of current technologies as well as the clinical impact of single-cell technologies in CVD patient care are highlighted, advocating for multidisciplinary and international collaborative efforts to join the cellular dots of CVD.

Publisher

Oxford University Press (OUP)

Subject

Cardiology and Cardiovascular Medicine

Link

https://academic.oup.com/eurheartj/article-pdf/44/14/1216/49783470/ehac686.pdf

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