Patent foramen ovale closure for secondary stroke prevention

Author:

Alkhouli Mohamad1,Sievert Horst2345,Holmes David R6

Affiliation:

1. Division of Cardiology, School of Medicine, West Virginia University, 1 Medical Center Drive, Morgantown, WV, USA

2. Department of Medicine, CardioVascular Center Frankfurt, Seckbacher Landstraße 65, Frankfurt am Main, Germany

3. Anglia Ruskin University, Cambridge Campus, East Rd, Cambridge, UK

4. Yunnan Hospital Fuwai, Intersection of Shahe Beilu and Jinchuan Lu, Kunming, China

5. University of California, 550 16th Street, San Francisco, CA, USA

6. Department of Cardiology, Mayo Clinic School of Medicine, 200 1st St SW, Rochester, MN, USA

Abstract

Abstract Transcatheter closure of patent foramen ovale (PFO) in patients with cryptogenic stroke is gaining momentum after the recent publication of four randomized clinical trials suggesting its benefit. This article provides a contemporary overview of the anatomy and pathophysiology of PFO, the available diagnostic tools for the assessment and risk stratification of PFO, and the current and future landscape of PFO closure devices and their optimal utilization. It also summarizes the current data on PFO closure for stroke prevention, and discusses the remaining open issues in the field of PFO closure.

Publisher

Oxford University Press (OUP)

Subject

Cardiology and Cardiovascular Medicine

Reference66 articles.

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4. Diagnosis of patent foramen ovale by transesophageal echocardiography and association with cerebral and peripheral embolic events;Hausmann;Am J Cardiol,1992

5. Patent foramen ovale and decompression sickness in divers;Moon;Lancet,1989

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