1. Newham University Hospital, Barts Health NHS Trust , London, E13 8SL , UK
2. Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust , London, EC1A 7BE , UK
3. NIHR Barts Biomedical Research Centre, William Harvey Research Institute, Queen Mary University of London , Charterhouse Square, London, EC1M 6BQ , UK
4. County Durham and Darlington NHS Foundation Trust , Darlington DL3 6HX
5. Department of Primary Care and Public Health, Imperial College London , W6 8RP , UK