Fulminant myocarditis proven by early biopsy and outcomes-Reference-Cited by-同舟云学术

Fulminant myocarditis proven by early biopsy and outcomes

Published:2023-11-06 Issue:48 Volume:44 Page:5110-5124
ISSN:0195-668X
Container-title:European Heart Journal
language:en
Short-container-title:

Author:

Huang Florent¹²^ORCID,Ammirati Enrico³,Ponnaiah Maharajah⁴^ORCID,Montero Santiago⁵^ORCID,Raimbault Victor²,Abrams Darryl⁶,Lebreton Guillaume⁷^ORCID,Pellegrino Vincent⁸,Ihle Joshua⁸,Bottiroli Maurizio³,Persichini Romain⁹,Barrionuevo-Sánchez Marisa Isabel¹⁰,Ariza-Solé Albert¹⁰,Ng Pauline Yeung¹¹,Sin Simon Wai Ching¹²,Ayer Raj¹³,Buscher Hergen¹³,Belaid Slimane¹⁴,Delmas Clément¹⁴,Ferreira Rita¹⁵,Roncon-Albuquerque Roberto¹⁵,Lόpez-Sobrino Teresa¹⁶,Bunge Jeroen J H¹⁷,Fisser Christoph¹⁸,Franchineau Guillaume¹⁹,McCanny Jamie²⁰,Ohshimo Shinichiro²¹,Sionis Alessandro²²^ORCID,Hernández-Pérez Francisco José²³,Barge-Caballero Eduardo²⁴,Balik Martin²⁵,Muglia Henrique²⁶,Park Sunghoon²⁷,Donker Dirk W²⁸²⁹,Porral Beatriz³⁰,Aïssaoui Nadia³¹,Mekontso Dessap Armand³²,Burgos Virginia³³,Lesouhaitier Mathieu³⁴,Fried Justin³⁵,Jung Jae-Seung³⁶,Rosillo Sandra³⁷,Scherrer Vincent³⁸,Nseir Saad³⁹,Winszewski Hadrien⁴⁰,Jorge-Pérez Pablo⁴¹,Kimmoun Antoine⁴²,Diaz Rodrigo⁴³,Combes Alain²⁴⁴,Schmidt Matthieu²⁴⁴^ORCID,Huang Florent,Kerneis Mathieu,Montalescot Gilles,Collet Jean Philippe,Delmas Clément,Belaid Slimane,Lavie-Badie Yoan,Biendel Caroline,Lesouhaitier Mathieu,Tadié Jean-Marc,Scherrer Vincent,Barge-Caballero Eduardo,Blanco-Canosa Paula,Grille-Cancela Zulaika,Porral Beatriz,Raposeiras Sergio,Rosillo Sandra,Lόpez-de-Sá Esteban,Sionis Alessandro,Hernando Víctor García,Lόpez-Sobrino Teresa,Riba Rut Andrea,Sandoval Elena,Burgos Virginia,Lera Marta Ruiz,Alvarez Angela Canteli,Bustamante Cristina Castrillo,Martínez Natalia Royuela,Martín Pablo Jorge-Pérez,García-González J,Martín-Cabeza Marta M,Miranda Dinis Reis,Bunge Jeroen J H,Caliskan Kadir,Fried Justin,Ching Simon Sin Wai,Jung Jae-Seung,Kim Jieon,Shin Hong Ju,Ohshimo Shinichiro,Kikutani Kazuya,Shime Nobuaki,

Affiliation:

1. Department of Cardiology, Foch Hospital , Suresnes , France

2. Medical Intensive Care Unit, Assistance Publique-Hôpitaux de Paris, Pitié-Salpêtrière Hospital , Paris Cedex 13 , France

3. De Gasperis Cardio Center and Transplant Center, Niguarda Hospital , Milan , Italy

4. ICAN Intelligence and Omics, Institute of Cardiometabolism and Nutrition, Pitié-Salpêtrière Hospital , Paris , France

5. Acute Cardiovascular Care Unit, Cardiology, Departament de Medicina, Hospital Germans Trias i Pujol, Universitat Autònoma de Barcelona , Spain

6. Columbia University College of Physicians and Surgeons/NewYork-Presbyterian Hospital and Center for Acute Respiratory Failure, Columbia University Medical Center , New York, NY , USA

7. Service de Chirurgie Cardiaque, Assistance Publique-Hôpitaux de Paris, Sorbonne Université , Paris Cedex 13 , France

8. Intensive Care Unit, Alfred Hospital , Melbourne , Australia

9. Medical-Surgical Intensive Care Unit, Félix Guyon Hospital , CHU de La Réunion , France

10. Intensive Cardiac Care Unit, Cardiology Department, Bioheart, Grup de Malalties Cardiovasculars, Institut d'Investigació Biomèdica de Bellvitge, IDIBELL, Bellvitge University Hospital , L'Hospitalet de Llobregat , Barcelona, Spain

11. Adult Intensive Care Unit, Queen Mary Hospital , Hong-Kong , China

12. Department of Anaesthesiology, The University of Hong Kong , Hong-Kong , China

13. Intensive Care Unit, St Vincent Hospital , Sydney , Australia

14. Department of Cardiology, Rangueil University Hospital , Toulouse , France

15. Intensive Care Unit, Saint João Hospital , Porto , Portugal

16. Department of Cardiology, Hospital Clínic Barcelona , Barcelona , Spain

17. Department of Intensive Care Adults, and Department of Cardiology, Erasmus Medical Center , Rotterdam , The Netherlands

18. Intensive Care Unit, University Medical Centre Regensburg , Regensburg , Germany

19. Department of Intensive Care Medicine and Infectious Diseases, Assistance Publique-Hôpitaux de Paris, Bichat-Claude Bernard Hospital, Sorbonne Université , Paris Cedex 18 , France

20. Intensive Care Unit, Guy’s and St Thomas’ NHS Foundation Trust Hospital , London , UK

21. Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University , Hiroshima , Japan

22. Intensive Cardiac Care Unit, Department of Cardiology, Hospital de la Santa Creu i Sant Pau, IIB-Sant Pau, Universitat Autònoma de Barcelona , Barcelona , Spain

23. Advanced Heart Failure and Transplant Unit, Department of Cardiology, Hospital Universitario Puerta de Hierro , Madrid , Spain

24. Cardiology Department, Complejo Hospitalario Universitario de A Coruña (CHUAC), Instituto de Investigación Biomédica de A Coruña (INIBIC), CIBERCV , A Coruña , Spain

25. Department of Anaesthesiology and Intensive Care, General University Hospital , Prague , Czech Republic

26. Intensive Care Unit, Erasme Hospital , Brussels , Belgium

27. Intensive Care Unit, Hallym University Sacred Heart Hospital , Anyang , South Korea

28. Intensive Care Center, University Medical Center Utrecht , Utrecht , The Netherlands

29. Cardiovascular and Respiratory Physiology, TechMed Center, University of Twente , Enschede , The Netherlands

30. Intensive Care Department, Hospital Alvaro Cunqueiro , Vigo , Spain

31. Intensive Care Unit, Cochin Hospital, Sorbonne Université, Assistance Publique-Hôpitaux de Paris , Paris Cedex 5 , France

32. Medical Intensive Care Unit, Assistance Publique-Hôpitaux de Paris, Mondor Hospital , Créteil , France

33. Acute Cardiac Care Unit, Department of Cardiology, Hospital Marqués de Valdecilla , Santander , Spain

34. Departement of Infectious Diseases and Intensive Care Unit, Pontchaillou Hospital , Rennes 35200 , France

35. Department of Cardiology, Columbia University Irving Medical Center/NewYork-Presbyterian Hospital , New York, NY , USA

36. Department of Thoracic and Cardiovascular Surgery, Korea University Anam Hospital , Seoul , South Korea

37. Department of Cardiology, Hospital Universitario La Paz, IDIPAZ , Madrid , Spain

38. Department of Anesthesiology and Critical Care, CHU Rouen , Rouen F-76000 , France

39. Médecine Intensive-Réanimation, Inserm U1285, CNRS, UMR 8576-UGSF-Unité de Glycobiologie Structurale et Fonctionnelle, CHU de Lille, University Lille , Lille , France

40. Intensive Care Unit, Jean-Minjoz Hospital , Besançon , France

41. Department of Cardiology, Hospital Universitario de Canarias Nuestra Señora de Candelaria , Canary Islands , Tenerife, Spain

42. CHRU de NANCY, Service de Médecine Intensive et Réanimation, Inserm U1116, Université de Lorraine , Nancy , France

43. Department of Cardiology, Clínica Las Condes , Las Condes , Chile

44. Sorbonne Université, INSERM UMRS_1166-iCAN, Institute of Cardiometabolism and Nutrition , Paris , France

Abstract

Abstract Background and Aims While endomyocardial biopsy (EMB) is recommended in adult patients with fulminant myocarditis, the clinical impact of its timing is still unclear. Methods Data were collected from 419 adult patients with clinically suspected fulminant myocarditis admitted to intensive care units across 36 tertiary centres in 15 countries worldwide. The diagnosis of myocarditis was histologically proven in 210 (50%) patients, either by EMB (n = 183, 44%) or by autopsy/explanted heart examination (n = 27, 6%), and clinically suspected cardiac magnetic resonance imaging confirmed in 96 (23%) patients. The primary outcome of survival free of heart transplantation (HTx) or left ventricular assist device (LVAD) at 1 year was specifically compared between patients with early EMB (within 2 days after intensive care unit admission, n = 103) and delayed EMB (n = 80). A propensity score-weighted analysis was done to control for confounders. Results Median age on admission was 40 (29–52) years, and 322 (77%) patients received temporary mechanical circulatory support. A total of 273 (65%) patients survived without HTx/LVAD. The primary outcome was significantly different between patients with early and delayed EMB (70% vs. 49%, P = .004). After propensity score weighting, the early EMB group still significantly differed from the delayed EMB group in terms of survival free of HTx/LVAD (63% vs. 40%, P = .021). Moreover, early EMB was independently associated with a lower rate of death or HTx/LVAD at 1 year (odds ratio of 0.44; 95% confidence interval: 0.22–0.86; P = .016). Conclusions Endomyocardial biopsy should be broadly and promptly used in patients admitted to the intensive care unit for clinically suspected fulminant myocarditis.

Publisher

Oxford University Press (OUP)

Subject

Cardiology and Cardiovascular Medicine

Link

https://academic.oup.com/eurheartj/article-pdf/44/48/5110/54585281/ehad707.pdf

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