1. Department of Cardiovascular, Renal and Metabolic Medicine, Sapporo Medical University School of Medicine , South-1, West-16, Chuo-ku, Sapporo 060-8543 , Japan
2. Department of Pediatrics, Faculty of Medicine and Graduate School of Medicine, Hokkaido University , Sapporo , Japan
3. Center for Medical Genetics, Department of Metabolism, Chiba Children’s Hospital , Chiba , Japan
4. Diagnostics and Therapeutics of Intractable Diseases, Intractable Disease Research Center, Graduate School of Medicine, Juntendo University , Tokyo , Japan