Adverse effects of statin therapy: perception vs. the evidence – focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract

Author:

Mach François1,Ray Kausik K2,Wiklund Olov34,Corsini Alberto5,Catapano Alberico L5,Bruckert Eric6,De Backer Guy7,Hegele Robert A8,Hovingh G Kees9,Jacobson Terry A10,Krauss Ronald M11,Laufs Ulrich12,Leiter Lawrence A13,März Winfried1415,Nordestgaard Børge G161718,Raal Frederick J19,Roden Michael2021,Santos Raul D2223,Stein Evan A24,Stroes Erik S9,Thompson Paul D25,Tokgözoğlu Lale26,Vladutiu Georgirene D27,Gencer Baris1,Stock Jane K28,Ginsberg Henry N29,Chapman M John30,

Affiliation:

1. Division of Cardiology, Department of Medical Specialties, Foundation for Medical Researches, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4 1205 Geneva, Switzerland

2. Imperial Centre for Cardiovascular Disease Prevention, Department of Primary Care and Public Health, School of Public Health, Imperial College London, London, UK

3. Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden

4. Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden

5. Department of Pharmacological and Biomolecular Sciences, University of Milan and IRCCS Multimedica, Milan, Italy

6. National Institute for Health and Medical Research (INSERM) UMRS1166, Department of Endocrinology-Metabolism, ICAN—Institute of CardioMetabolism and Nutrition, AP-HP, Hôpital de la Pitié, Paris, France

7. Department of Public Health, University Hospital Ghent, Ghent, Belgium

8. Department of Medicine, Robarts Research Institute, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada

9. Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands

10. Department of Medicine, Emory University, Atlanta, GA, USA

11. Department of Atherosclerosis Research, Children's Hospital Oakland Research Institute, Oakland, CA, USA

12. Department of Cardiology, University of Leipzig, Leipzig, Germany

13. Li Ka Shing Knowledge Institute of St Michael's Hospital, University of Toronto, Toronto, ON, Canada

14. Vth Department of Medicine (Nephrology, Hypertensiology, Endocrinology, Diabetology, Rheumatology), Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany

15. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University Graz, Graz, Austria

16. Department of Clinical Biochemistry and The Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark

17. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

18. The Copenhagen City Heart Study, Frederiksberg Hospital, Copenhagen University Hospital, Copenhagen, Denmark

19. Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa

20. German Center for Diabetes Research (DZD), München-Neuherberg, Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Düsseldorf, Germany

21. Department of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany

22. Hospital Israelita Albert Einstein, São Paulo, Brazil

23. Heart Institute (InCor), University of São Paulo Medical School Hospital, São Paulo, Brazil

24. Metabolic and Atherosclerosis Research Center, Cincinnati, OH, USA

25. Hartford Hospital, Hartford, CT, USA

26. Department of Cardiology, Hacettepe University, Ankara, Turkey

27. Jacobs School of Medicine & Biomedical Sciences, University at Buffalo, The State University of New York, New York, USA

28. European Atherosclerosis Society, Gothenburg, Sweden

29. Department of Medicine, Columbia University College of Physicians and Surgeons, New York, USA

30. National Institute for Health and Medical Research (INSERM), and University of Pierre and Marie Curie—Paris 6, Pitié Salpêtrière, Paris, France

Funder

European Atherosclerosis Society

Amgen, AstraZeneca, Eli Lilly, Esperion, Merck, Pfizer, and Sanofi-Regeneron

Publisher

Oxford University Press (OUP)

Subject

Cardiology and Cardiovascular Medicine

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