1. Division of Cardiovascular Medicine, BHF Centre of Research Excellence, University of Oxford, UK
2. Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford , Oxford , UK
3. Medical Research Council Population Health Research Unit, Nuffield Department of Population Health, University of Oxford , Oxford , UK
4. Department of Cardiovascular Surgery, State Key Laboratory of Cardiovascular Disease, National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing , China