Repurposing of an antiasthmatic drug may reduce NETosis and myocardial ischaemia/reperfusion injury

Author:

Amponsah-Offeh Michael12ORCID,Tual-Chalot Simon3ORCID,Stellos Konstantinos1234ORCID

Affiliation:

1. Department of Cardiovascular Research, European Center for Angioscience, Medical Faculty Mannheim, Heidelberg University , Ludolf-Krehl-Straße 13–17, D-68167 Mannheim , Germany

2. German Centre for Cardiovascular Research (DZHK), Partner Site Heidelberg/Mannheim , Mannheim , Germany

3. Biosciences Institute, Vascular Biology and Medicine Theme, Faculty of Medical Sciences, Newcastle University , Newcastle upon Tyne , UK

4. Preventive Cardiology Clinic, Department of Cardiology, University Hospital Mannheim, Medical Faculty Mannheim, Heidelberg University , Mannheim , Germany

Funder

British Heart Foundation

Royal Society

European Research Council

European Union’s Horizon 2020

MODVASC

Biotechnology and Biological Sciences Research Council of UK Research and Innovation

German Research Foundation Deutsche Forschungsgemeinschaft

Health + Life Science Alliance Heidelberg Mannheim

Helmholtz Association

Publisher

Oxford University Press (OUP)

Reference15 articles.

1. Targeting reperfusion injury in patients with ST-segment elevation myocardial infarction: trials and tribulations;Hausenloy;Eur Heart J,2017

2. Effector T cell chemokine IP-10 predicts cardiac recovery and clinical outcomes post-myocardial infarction;Sopova;Front Immunol,2023

3. Neutrophil extracellular traps: from physiology to pathology;Hidalgo;Cardiovasc Res,2022

4. Endothelial dysfunction and immunothrombosis in sepsis;Maneta;Front Immunol,2023

5. Mitochondria in acute myocardial infarction and cardioprotection;Ramachandra;EBioMedicine,2020

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