A novel but frequent variant in LPA KIV-2 is associated with a pronounced Lp(a) and cardiovascular risk reduction-Reference-Cited by-同舟云学术

A novel but frequent variant in LPA KIV-2 is associated with a pronounced Lp(a) and cardiovascular risk reduction

Published:2017-04-25 Issue:23 Volume:38 Page:1823-1831
ISSN:0195-668X
Container-title:European Heart Journal
language:en
Short-container-title:

Author:

Coassin Stefan¹,Erhart Gertraud¹,Weissensteiner Hansi¹,Eca Guimarães de Araújo Mariana²,Lamina Claudia¹,Schönherr Sebastian¹,Forer Lukas¹,Haun Margot¹,Losso Jamie Lee¹,Köttgen Anna³,Schmidt Konrad¹,Utermann Gerd⁴,Peters Annette⁵⁶⁷,Gieger Christian⁶⁸,Strauch Konstantin⁹¹⁰,Finkenstedt Armin¹¹,Bale Reto¹²,Zoller Heinz¹¹,Paulweber Bernhard¹³,Eckardt Kai-Uwe¹⁴,Hüttenhofer Alexander¹⁵,Huber Lukas A.²,Kronenberg Florian¹

Affiliation:

1. Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Schoepfstrasse 41, 6020 Innsbruck, Austria

2. Division of Cell Biology, Biocenter, Medical University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria

3. Division of Genetic Epidemiology, Division of Genetic Epidemiology - Faculty of Medicine and Medical Center - University of Freiburg, Hugstetter Strasse 49, 79106 Freiburg, Germany

4. Division of Human Genetics, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Peter-Mayr-Strasse 1, 6020 Innsbruck, Austria

5. German Center for Diabetes Research, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany

6. Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany

7. Munich Heart Alliance, German Center for Cardiovascular Disease Research, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany

8. Research Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany

9. Institute of Genetic Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany

10. Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Marchioninistrasse 15, 81377 Munich, Germany

11. Internal Medicine I, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria

12. Section of Interventional Oncology - Microinvasive Therapy (SIP), Department of Radiology, Medical University Innsbruck, Anichstrasse 35, 6020 Innsbruck, Austria

13. First Department of Internal Medicine, Paracelsus Private Medical University, Müllner Hauptstrasse 48, 5020 Salzburg, Austria

14. Department of Nephrology and Hypertension, University of Erlangen-Nürnberg, Ulmenweg 18, 91054 Erlangen, Germany

15. Division of Genomics and RNomics, Biocenter, Medical University of Innsbruck, Innrain 80-82, 6020 Innsbruck, Austria

Funder

intramural funding program of the Medical University of Innsbruck for young scientists MUI-START

Christine Katharine Schmitz Foundation

Austrian Science Fund (FWF)

Publisher

Oxford University Press (OUP)

Subject

Cardiology and Cardiovascular Medicine

Link

http://academic.oup.com/eurheartj/article-pdf/38/23/1823/24120437/ehx174.pdf

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4. Apolipoprotein(a) isoforms and the risk of vascular disease: systematic review of 40 studies involving 58,000 participants;Erqou;J Am Coll Cardiol,2010

5. Lp(a) glycoprotein phenotypes. Inheritance and relation to Lp(a)-lipoprotein concentrations in plasma;Utermann;J Clin Invest,1987

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