Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study-Reference-Cited by-同舟云学术

Clinical presentation, aetiology and outcome of infective endocarditis. Results of the ESC-EORP EURO-ENDO (European infective endocarditis) registry: a prospective cohort study

Published:2019-09-03 Issue:39 Volume:40 Page:3222-3232
ISSN:0195-668X
Container-title:European Heart Journal
language:en
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Author:

Habib Gilbert¹²^ORCID,Erba Paola Anna³⁴^ORCID,Iung Bernard⁵^ORCID,Donal Erwan⁶,Cosyns Bernard⁷^ORCID,Laroche Cécile⁸,Popescu Bogdan A⁹,Prendergast Bernard¹⁰,Tornos Pilar¹¹,Sadeghpour Anita¹²,Oliver Leopold¹³,Vaskelyte Jolanta-Justina¹⁴,Sow Rouguiatou¹⁵^ORCID,Axler Olivier¹⁶,Maggioni Aldo P¹⁷,Lancellotti Patrizio¹⁸¹⁹²⁰,Gale C P,Beleslin B,Budaj A,Chioncel O,Dagres N,Danchin N,Emberson J,Erlinge D,Glikson M,Gray A,Kayikcioglu M,Maggioni A P,Nagy V K,Nedoshivin A,Petronio A-S,Roos-Hesselink J,Wallentin L,Zeymer U,Habib G,Lancellotti P,Cosyns B,Donal E,Erba P,Iung B,Maggioni A P,Popescu B A,Prendergast B,Tornos P,Andarala M,Berle C,Brunel-Lebecq A,Fiorucci E,Laroche C,Missiamenou V,Taylor C,Ali Tatar-Chentir N N,Al-Mallah M,Astrom Aneq M,Athanassopoulos G,Badano L P,Benyoussef S,Calderon Aranda E,Cardim N M,Chan K-L,Cosyns B,Cruz I,Edvardsen T,Goliasch G,Habib G,Hagendorff A,Hristova K,Iung B,Kamp O,Kang D-H,Kong W,Matskeplishvili S,Meshaal M,Mirocevic M,Neskovic A N,Pazdernik M,Plonska-Gosciniak E,Popescu B A,Prendergast B,Raissouni M,Ronderos R,Sade L E,Sadeghpour A,Sambola A,Sengupta S,Separovic-Hanzevacki J,Takeuchi M,Tucay E,Tude Rodrigues A C,Varga A,Vaskelyte J,Yamagata K,Yiangou K,Zaky H,Granada I,Mahia M,Ressi S,Nacinovich F,Iribarren A,Fernandez Oses P,Avegliano G,Filipini E,Obregon R,Bangher M,Dho J,Cartasegna L,Plastino M L,Novas V,Shigel C,Reyes G,De Santos M,Gastaldello N,Granillo Fernandez M,Potito M,Streitenberger G,Velazco P,Casabé J H,Cortes C,Guevara E,Salmo F,Seijo M,Weidinger F,Heger M,Brooks R,Stöllberger C,Ho C-Y,Perschy L,Puskas L,Binder C,Rosenhek R,Schneider M,Winter M-P,Hoffer E,Melissopoulou M,Lecoq E,Legrand D,Jacquet S,Massoz M,Pierard L,Marchetta S,Dulgheru R,Emal C D´,Oury C,Droogmans S,Kerkhove D,Plein D,Soens L,Weytjens C,Motoc A,Roosens B,Lemoine I,Rodrigus I,Paelinck B,Amsel B,Unger P,Konopnicki D,Beauloye C,Pasquet A,Vanoverschelde J L,Pierard S,Vancraeynest D,Sinnaeve F,Andrade J L,Staszko K,Dos Santos Monteiro 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K,Papadopoulos C,Kiokas S,Lioni A,Misailidou S,Barbetseas J,Bonou M,Kapelios C,Tomprou I,Zerva K,Manolis A,Hamodraka E,Athanasiou D,Haralambidis G,Samaras H,Poulimenos L,Nagy A,Bartykowszki A,Gara E,Mungulmare K,Kasliwal R,Bansal M,Ranjan S,Bhan A,Kyavar M,Maleki M,Noohi Bezanjani F,Alizadehasl A,Boudagh S,Ghavidel A,Moradnejad P,Pasha H R,Ghadrdoost B,Gilon D,Strahilevitz J,Wanounou M,Israel S,d'Agostino C,Colonna P,De Michele L,Fumarola F,Stante M,Marchionni N,Scheggi V,Alterini B,Del Pace S,Stefano P,Sparano C,Ruozi N,Tenaglia R,Muraru D,Limbruno U,Cresti A,Baratta P,Solari M,Giannattasio C,Moreo A,De Chiara B,Lopez Montero B,Musca F,Orcese C A,Panzeri F,Spano F,Russo C F,Alfieri O,De Bonis M,Chiappetta S,Del Forno B,Ripa M,Scarpellini P,Tassan Din C,Castiglioni B,Pasciuta R,Carletti S,Ferrara D,Guffanti M,Iaci G,Lapenna E,Nisi T,Oltolini C,Busnardo E,Pajoro U,Agricola E,Meneghin R,Schiavi D,Piscione F,Citro R,Benvenga R M,Greco L,Soriente L,Radano I,Prota C,Bellino M,Di Vece 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T,Farrugia J,Fenech M,Pllaha E,Vella C,Borg D,Casha R,Grib L,Raevschi E,Grejdieru A,Kravcenco D,Prisacari E,Samohvalov E,Samohvalov S,Sceglova N,Panfile E,Cardaniuc L,Corcea V,Feodorovici A,Gaina V,Girbu L,Jimbei P,Balan G,Cardaniuc I,Benesco I,Marian V,Sumarga N,Bozovic B,Bulatovic N,Lakovic P,Music L,Budde R,Wahadat A,Gamela T,Meijers T,Van Melle J P,Deursen V M,Crijns H J,Bekkers S C,Cheriex E C,Gilbers M,Kietselaer B L,Knackstedt C,Lorusso R,Schalla S,Streukens S A,Chamuleau S,Cramer M-J,Teske A,Van der Spoel T,Wind A,Lokhorst J,Liesbek O,Van Heusden H,Tanis W,Van der Bilt I,Vriend J,De Lange-van Bruggen H,Karijodikoro E,Riezebos R,van Dongen E,Schoep J,Stolk V,Offstad J T,Beitnes J O,Helle-Valle T,Skulstad H,Skardal R,Qamar N,Furnaz S,Ahmed B,Butt M H,Khanzada M F,Saghir T,Wahid A,Hryniewiecki T,Szymanski P,Marzec K,Misztal-Ogonowska M,Kosmala W,Przewlocka-Kosmala M,Rojek A,Woznicka K,Zachwyc J,Lisowska A,Kaminska M,Kasprzak J D,Kowalczyk E,Strzecka D F,Wejner-Mik P,Trabulo 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Affiliation:

1. Cardiology Department, APHM, La Timone Hospital, Boulevard Jean Moulin, Marseille, France

2. Aix Marseille University, IRD, APHM, MEPHI, IHU-Méditerranée Infection, Marseille, France

3. Nuclear Medicine, Department of Translational Research and New Technology, Medicine University of Pisa and Azienda Ospedaliero Universitaria Pisana, Pisa, Italy

4. Medical Imaging Center, University Medical Center Groningen, Groningen, The Netherlands

5. Bichat Hospital, APHP, DHU Fire, Paris Diderot University, Paris, France

6. University of Rennes, CHU Rennes, Inserm, LTSI – UMR 1099, Rennes, France

7. Center for Cardiovascular Diseases (CHVZ), University Hospital Brussel, Brussels, Belgium

8. EURObservational Research Programme (EORP), European Society of Cardiology, Sophia-Antipolis, France

9. Department of Cardiology, University of Medicine and Pharmacy “Carol Davila” Euroecolab, Emergency Institute of Cardiovascular Diseases “Prof. Dr C. C. Iliescu”, Bucharest, Romania

10. Department of Cardiology, Guy's and St Thomas' Hospital, London, Great Britain

11. Department of Cardiology, Hospital Quiron Barcelona

12. Echocardiography Research Center, Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran

13. Department of Cardiovascular Medicine, SOS Endocardites Unit, Henri-Mondor University Hospital, AP-HP, Creteil, France

14. Department of Cardiology, Lithuanian University of Health Sciences, Kaunas, Lithuania

15. Luxembourg Hospital Centre, Luxembourg

16. Cardiology Department, Gaston Bourret Hospital Centre, New Caledonia University, Noumea, New Caledonia, France

17. EURObservational Research Programme, European Society of Cardiology, France

18. ANMCO Research Center, Florence, Italy

19. Department of Cardiology, Heart Valve Clinic, University of Liege Hospital, GIGA Cardiovascular Sciences, CHU Sart Tilman, Liege, Belgium

20. Gruppo Villa Maria Care and Research, Anthea Hospital, Bari, Italy

Abstract

Abstract Aims The EURO-ENDO registry aimed to study the management and outcomes of patients with infective endocarditis (IE). Methods and results Prospective cohort of 3116 adult patients (2470 from Europe, 646 from non-ESC countries), admitted to 156 hospitals in 40 countries between January 2016 and March 2018 with a diagnosis of IE based on ESC 2015 diagnostic criteria. Clinical, biological, microbiological, and imaging [echocardiography, computed tomography (CT) scan, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT)] data were collected. Infective endocarditis was native (NVE) in 1764 (56.6%) patients, prosthetic (PVIE) in 939 (30.1%), and device-related (CDRIE) in 308 (9.9%). Infective endocarditis was community-acquired in 2046 (65.66%) patients. Microorganisms involved were staphylococci in 1085 (44.1%) patients, oral streptococci in 304 (12.3%), enterococci in 390 (15.8%), and Streptococcus gallolyticus in 162 (6.6%). 18F-fluorodeoxyglucose positron emission tomography/computed tomography was performed in 518 (16.6%) patients and presented with cardiac uptake (major criterion) in 222 (42.9%) patients, with a better sensitivity in PVIE (66.8%) than in NVE (28.0%) and CDRIE (16.3%). Embolic events occurred in 20.6% of patients, and were significantly associated with tricuspid or pulmonary IE, presence of a vegetation and Staphylococcus aureus IE. According to ESC guidelines, cardiac surgery was indicated in 2160 (69.3%) patients, but finally performed in only 1596 (73.9%) of them. In-hospital death occurred in 532 (17.1%) patients and was more frequent in PVIE. Independent predictors of mortality were Charlson index, creatinine > 2 mg/dL, congestive heart failure, vegetation length > 10 mm, cerebral complications, abscess, and failure to undertake surgery when indicated. Conclusion Infective endocarditis is still a life-threatening disease with frequent lethal outcome despite profound changes in its clinical, microbiological, imaging, and therapeutic profiles.

Funder

Abbott Vascular Int.

Amgen Cardiovascular

AstraZeneca

Bayer AG

Boehringer Ingelheim

Boston Scientific

Bristol Myers Squibb

Pfizer Alliance

Daiichi Sankyo Europe GmbH

Alliance Daiichi Sankyo Europe GmbH

Eli Lilly and Company