1. Medical Research Council Biostatistics Unit, University of Cambridge, Cambridge CB2 0SR, UK
2. Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
3. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London W2 1PG, UK
4. Clinical Pharmacology and Therapeutics Section, Institute of Medical and Biomedical Education and Institute for Infection and Immunity, St George’s, University of London, London SW17 0RE, UK
5. Clinical Pharmacology Group, Pharmacy and Medicines Directorate, St George’s University Hospitals NHS Foundation Trust, London SW17 0QT, UK
6. Genetics Department, Novo Nordisk Research Centre Oxford, Old Road Campus, Oxford OX3 7FZ, UK