1. Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
2. Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan
3. Division of Brain Sciences, Department of Medicine, Imperial College London, London, UK
4. National Cerebral and Cardiovascular Center, Suita, Japan
5. International University of Health and Welfare, Narita, Japan