Predictors of embolism and death in left-sided infective endocarditis: the European Society of Cardiology EURObservational Research Programme European Infective Endocarditis registry-Reference-Cited by-同舟云学术

Predictors of embolism and death in left-sided infective endocarditis: the European Society of Cardiology EURObservational Research Programme European Infective Endocarditis registry

Published:2023-08-18 Issue:43 Volume:44 Page:4566-4575
ISSN:0195-668X
Container-title:European Heart Journal
language:en
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Author:

Sambola Antonia¹^ORCID,Lozano-Torres Jordi¹^ORCID,Boersma Eric²^ORCID,Olmos Carmen³^ORCID,Ternacle Julien⁴^ORCID,Calvo Francisco⁵^ORCID,Tribouilloy Christophe⁶^ORCID,Reskovic-Luksic Vlatka⁷^ORCID,Separovic-Hanzevacki Jadranka⁷^ORCID,Park Seung-Woo⁸^ORCID,Bekkers Sebastiaan⁹^ORCID,Chan Kwan-Leung¹⁰,Almaghraby Abdallah¹¹^ORCID,Iung Bernard¹²^ORCID,Lancellotti Patrizio¹³¹⁴^ORCID,Habib Gilbert¹⁵¹⁶^ORCID,Ferrari R,Alonso A,Bax J,Blomström-Lundqvist C,Gielen S,Maggioni A P,Lancellotti P,Maniadakis N,Pinto F,Ruschitzka F,Tavazzi L,Vardas P,Weidinger F,Zeymer U,Vahanian A,Budaj A,Dagres N,Danchin N,Delgado V,Emberson J,Friberg O,Gale C P,Heyndrickx G,Iung B,James S,Kappetein A P,Maggioni A P,Maniadakis N,Nagy K V,Parati G,Petronio A-S,Pietila M,Prescott E,Ruschitzka F,Van de Werf F,Weidinger F,Zeymer U,Habib Gilbert,Lancellotti Patrizio,Cosyns Bernard,Donal Erwan,Erba Paola,Habib Gilbert,Iung Bernard,Maggioni Aldo P,Popescu Bogdan A,Prendergast Bernard,Tornos Pilar,Tatar-Chentir Nora Nabila Ali,Al-Mallah Mouaz,Aneq Meriam Astrom,Athanassopoulos George,Badano Luigi Paolo,Benyoussef Soraya,Aranda Erick Calderon,Cardim Nuno Miguel,Chan Kwan-Leung,Cosyns Bernard,Cruz Ines,Edvardsen Thor,Goliasch Georg,Habib Gilbert,Hagendorff Andreas,Hristova Krasimira,Iung Bernard,Kamp Otto,Kang Duk-Hyun,Kong William,Matskeplishvili Simon,Meshaal Marwa,Mirocevic Maja,Neskovic Aleksandar N,Pazdernik Michal,Plonska-Gosciniak Edyta,Popescu Bogdan A,Prendergast Bernard,Raissouni Maha,Ronderos Ricardo,Sade Leyla Elif,Sadeghpour Anita,Sambola Antonia,Sengupta Shantanu,Separovic-Hanzevacki Jadranka,Takeuchi Masaaki,Tucay Edwin,Rodrigues Ana Clara Tude,Varga Albert,Vaskelyte Jolanta,Yamagata Kentaro,Yiangou Kyriakos,Zaky Hosam,Ronderos R,Avegliano G,Fernandez Oses P,Filipini E,Granada I,Iribarren A,Mahia M,Nacinovich F,Ressi S,Obregon R,Bangher M,Dho J,Cartasegna L,Plastino M L,Novas V,Shigel C,Reyes G,De Santos M,Gastaldello N,Granillo Fernandez M,Potito M,Streitenberger G,Velazco P,Casabé J H,Cortes C,Guevara E,Salmo F,Seijo M,Weidinger F,Heger M,Brooks R,Stöllberger C,Ho C-Y,Perschy L,Puskas L,Goliasch G,Binder C,Rosenhek R,Schneider M,Winter M-P,Hoffer E,Melissopoulou M,Lecoq E,Legrand D,Jacquet S,Massoz M,Lancellotti P,Pierard L,Dulgheru R,Marchetta S,D’Emal C,Oury C,Cosyns B,Droogmans S,Kerkhove D,Motoc A,Plein D,Roosens B,Soens L,Weytjens C,Lemoine I,Rodrigus I,Paelinck B,Amsel B,Unger P,Konopnicki D,Beauloye C,Pasquet A,Pierard S,Vancraeynest D,Vanoverschelde J L,Sinnaeve F,Andrade J L,Tude Rodrigues A C,Staszko K,Dos Santos Monteiro R,Miglioranza M H,Shuha D L,Alcantara M,Cravo V,Fazzio L,Felix A,Iso M,Musa C,Siciliano A P,Villaca Filho F,Braga J,Rodrigues A,Silva R,Vilela F,Rodrigues D,Silva L,Morhy S,Fischer C,Silva R,Vieira M,Afonso T,Abreu J,Falcao S N,Moises V,Gouvea A,João G,Mancuso F,Silva C,Souza A C,Abboud C S,Bellio de Mattos Barretto R,Ramos A,Arnoni R,Assef J E,Della Togna D J,Le Bihan D,Miglioli L,Romero Oliveira A P,Tadeu Magro Kroll R,Cortez D,Gelape 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L,Buisson M,Mahy S,Martins C,Salmon-Rousseau A,Gohier S,Piper C,Börgermann J,Guckel D,Horstkotte D,Brockmeier B,Winkelmann E,Hagendorff A,Grey D,Nickenig G,Schueler R,Öztürk C,Stöhr E,Hamm C,Walther T,Brandt R,Frühauf A-C,Hartung C T,Hellner C,Wild C,Becker M,Hamada S,Kaestner W,Stangl K,Knebel F,Baldenhofer G,Brecht A,Dreger H,Isner C,Pfafflin F,Stegemann M,Zahn R,Fraiture B,Kilkowski C,Karcher A-K,Klinger S,Tolksdorf H,Tousoulis D,Aggeli C,Sarri G,Sideris S,Venieri E,Athanassopoulos G,Tsiapras D,Armenis I,Koutsiari A,Floros G,Grassos C,Dragasis S,Rallidis L,Varlamos C,Michalis L,Naka K,Bechlioulis A,Kotsia A,Lakkas L,Pappas K,Papadopoulos C,Kiokas S,Lioni A,Misailidou S,Barbetseas J,Bonou M,Kapelios C,Tomprou I,Zerva K,Manolis A,Hamodraka E,Athanasiou D,Haralambidis G,Poulimenos L,Samaras H,Nagy A,Bartykowszki A,Gara E,Sengupta S,Mungulmare K,Kasliwal R,Bansal M,Bhan A,Ranjan S,Kyavar M,Maleki M,Noohi Bezanjani F,Sadeghpour A,Alizadehasl A,Boudagh S,Ghavidel A,Moradnejad P,Pasha H 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Affiliation:

1. Department of Cardiology and Research Institute, Cardiac Intensive Care Unit, University Hospital Valld’Hebron, Universitat Autònoma, CIBER Cardiovascular Diseases (CIBER-CV) , P° Vall d’Hebron, 119-129, Barcelona 08035 , Spain

2. Department of Cardiology, Erasmus MC Cardiovascular Institute, University Medical Center Rotterdam , BOX 2040, 3000 CA, Rotterdam , The Netherlands

3. Instituto cardiovascular, Hospital Clínico San Carlos , Instituto de investigación Sanitaria del Hospital Clínico San Carlos, Prof. Martín Lagos s/n, 28040 Madrid , Spain

4. Department of Cardiology, SOS Endocarditis, Henri Mondor University Hospital , Creteil , France

5. Department of Cardiology, Hospital Universitario Alvaro Cunqueiro , Vigo , Spain

6. Department of Cardiology, University Hospital of Amiens , Amiens , France

7. Department of Cardiovascular Diseases, School of Medicine, University Hospital Centre Zagreb , Zagreb , Croatia

8. Heart Vascular Stroke Institute, Samsung Medical Center , Sungkyunkwan University School of Medicine, Seoul , Republic of Korea

9. Cardiovascular Research Institute Maastricht (CAARIM), Maastricht University Medical Centre (MUMC) , Maastricht , The Netherlands

10. University of Ottawa Heart Institute , Ottawa, Ontario, Canada

11. Cardiology Department, Alexandria University Hospital, Alexandria, Egypt

12. Cardiology Department, AP-HP, Hôpital Bichat , Paris , France

13. ANMCO Research Center , Florence, Italy

14. Department of Cardiology, Heart valve Clinic, University of Liege Hospital , Liege , Belgium

15. Cardiology Department, APHM, La Timone Hospital , Marseille , France

16. Aix Marseille University, IRD, APHM, MEPHI, IHU-Méditerranée Infection , Marseille , France

Abstract

Abstract Background and Aims Even though vegetation size in infective endocarditis (IE) has been associated with embolic events (EEs) and mortality risk, it is unclear whether vegetation size associated with these potential outcomes is different in left-sided IE (LSIE). This study aimed to seek assessing the vegetation cut-off size as predictor of EE or 30-day mortality for LSIE and to determine risk predictors of these outcomes. Methods The European Society of Cardiology EURObservational Research Programme European Infective Endocarditis is a prospective, multicentre registry including patients with definite or possible IE throughout 2016–18. Cox multivariable logistic regression analysis was performed to assess variables associated with EE or 30-day mortality. Results There were 2171 patients with LSIE (women 31.5%). Among these affected patients, 459 (21.1%) had a new EE or died in 30 days. The cut-off value of vegetation size for predicting EEs or 30-day mortality was >10 mm [hazard ratio (HR) 1.38, 95% confidence interval (CI) 1.13–1.69, P = .0015]. Other adjusted predictors of risk of EE or death were as follows: EE on admission (HR 1.89, 95% CI 1.54–2.33, P < .0001), history of heart failure (HR 1.53, 95% CI 1.21–1.93, P = .0004), creatinine >2 mg/dL (HR 1.59, 95% CI 1.25–2.03, P = .0002), Staphylococcus aureus (HR 1.36, 95% CI 1.08–1.70, P = .008), congestive heart failure (HR 1.40, 95% CI 1.12–1.75, P = .003), presence of haemorrhagic stroke (HR 4.57, 95% CI 3.08–6.79, P < .0001), alcohol abuse (HR 1.45, 95% CI 1.04–2.03, P = .03), presence of cardiogenic shock (HR 2.07, 95% CI 1.29–3.34, P = .003), and not performing left surgery (HR 1.30 95% CI 1.05–1.61, P = .016) (C-statistic = .68). Conclusions Prognosis after LSIE is determined by multiple factors, including vegetation size.

Funder

Abbott Vascular Int

Amgen Cardiovascular

AstraZeneca

Bayer AG

Boehringer Ingelheim

Boston Scientific

The Bristol Myers Squibb and Pfizer Alliance

Daiichi Sankyo Europe GmbH

The Alliance Daiichi Sankyo Europe GmbH and Eli Lilly and Company

Edwards

Gedeon Richter Plc.