Susceptibility of low-density lipoprotein particles to aggregate depends on particle lipidome, is modifiable, and associates with future cardiovascular deaths

Author:

Ruuth Maija12,Nguyen Su Duy1,Vihervaara Terhi3,Hilvo Mika3,Laajala Teemu D45,Kondadi Pradeep Kumar6,Gisterå Anton7,Lähteenmäki Hanna1,Kittilä Tiia1,Huusko Jenni8,Uusitupa Matti9,Schwab Ursula910,Savolainen Markku J1112,Sinisalo Juha13,Lokki Marja-Liisa14,Nieminen Markku S13,Jula Antti15,Perola Markus1516,Ylä-Herttula Seppo817,Rudel Lawrence18,Öörni Anssi19,Baumann Marc20,Baruch Amos21,Laaksonen Reijo32223,Ketelhuth Daniel F J7,Aittokallio Tero45,Jauhiainen Matti1524,Käkelä Reijo2526,Borén Jan6,Williams Kevin Jon6,Kovanen Petri T1,Öörni Katariina125

Affiliation:

1. Atherosclerosis Research Laboratory, Wihuri Research Institute, Haartmaninkatu 8, 00290 Helsinki, Finland

2. Research Programs Unit, Faculty of Medicine, University of Helsinki, Haartmaninkatu 8, P.O. Box 63, 00014 University of Helsinki, Finland

3. Zora Biosciences, Biologinkuja 1, 02150 Espoo, Finland

4. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Tukholmankatu 8, P.O. Box 20, 00014 University of Helsinki, Finland

5. Department of Mathematics and Statistics, University of Turku, Vesilinnantie 5, 20014 University of Turku, Finland

6. Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, SU Sahlgrenska, 41345 Gothenburg, Sweden

7. Department of Medicine, Karolinska University Hospital, Karolinska Institute, Solna 171 76 Stockholm, Sweden

8. Department of Biotechnology and Molecular Medicine, A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, 70211 Kuopio, Finland

9. Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, 70211 Kuopio, Finland

10. Institute of Clinical Medicine, Internal Medicine, Kuopio University Hospital, Puijonlaaksontie 2, P.O. Box 100, 70029 Kuopio, Finland

11. Research Unit of Internal Medicine, University of Oulu, Pentti Kaiteran katu 1, P.O. Box 8000, 90014, Oulu, Finland

12. Medical Research Center, Oulu University Hospital, Pentti Kaiteran katu 1, P.O. Box 8000, 90014 Oulu, Finland

13. Heart and Lung Center, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4, P.O. Box 340, 00029 Helsinki, Finland

14. Transplantation Laboratory, Medicum, University of Helsinki, Haartmaninkatu 3, P.O. Box 21, 00014 Helsinki, Finland

15. Genomics and Biomarkers Unit, Department of Health, National Institute for Health and Welfare, Genomics and Biomarkers Unit, Mannerheimintie 166, P.O. Box 30, 00271 Helsinki, Finland

16. Institute for Molecular Medicine Finland and Diabetes and Obesity Research Program, University of Helsinki, Haartmaninkatu 8, P.O. Box 63, 00014 University of Helsinki, Finland

17. Heart Center and Gene Therapy Unit, Kuopio University Hospital, Puijonlaaksontie 2, P.O. Box 100, 70029 Kuopio, Finland

18. Department of Biochemistry Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA

19. Information Systems, Åbo Akademi University, Fänriksgatan 3A, 20500 Turku, Finland

20. Meilahti Clinical Proteomics Core Facility, Faculty of Medicine, University of Helsinki, Haartmaninkatu 8, P.O. Box 63, 00014 University of Helsinki, Finland

21. Genentech Research and Early Development, 1 DNA Way Mailstop 258A, South San Francisco, CA 94080, USA

22. Finnish Cardiovascular Research Center, University of Tampere, Kalevantie 4, 33100 Tampere, Finland

23. Finnish Clinical Biobank Tampere, University Hospital of Tampere, Arvo Ylpön katu 6, 33520 Tampere, Finland

24. Minerva Foundation Institute for Medical Research, Tukholmankatu 8, 00290 Helsinki, Finland

25. Molecular and Integrative Biosciences Research Programme, Faculty of Biological and Environmental Sciences, University of Helsinki, Viikinkaari 1, P.O. Box 65, 00014 University of Helsinki, Finland

26. Helsinki University Lipidomics Unit, Helsinki Institute for Life Science (HiLIFE), Viikinkaari 1, P.O. Box 65, 00014 University of Helsinki, Finland

Funder

Antti Wihuri Foundation

Finnish Foundation for Cardiovascular Research

Academy of Finland

Magnus Ehrnrooth Foundation

Jane and Aatos Erkko Foundation

Swedish Heart-Lung Foundation

Publisher

Oxford University Press (OUP)

Subject

Cardiology and Cardiovascular Medicine

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