1. Department of Cardiovascular Medicine, Fondazione Policlinico Universitario A. Gemelli—IRCCS , Largo A. Gemelli 8, Rome 00168 , Italy
2. Cardiovascular and Pulmonary Sciences, Catholic University, School of Medicine , Largo F. Vito, 1—00168 Rome , Italy
3. Pharmacology, Catholic University School of Medicine , Largo F. Vito, 1—00168 Rome , Italy