1. Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh11451, Kingdom of Saudi Arabia
2. Cardiovascular Prevention and Control Program, Ministry of Health, Riyadh 11176, Kingdom of Saudi Arabia
3. Imperial Clinical Trials Unit, Imperial College London, Stadium House, 68 Wood Lane, London W12 7RH, UK
4. Department of Primary Care and Public Health, Imperial College London, St Dunstan’s Road, London W6 8RP, UK
5. Department of Mathematics, Huxley Building, South Kensington Campus, Imperial College London, London SW7 2AZ, UK