1. From the Departments of Clinical Medicine (AMM) and Biochemistry (JMS), Trinity College Dublin, Dublin, Ireland; the Health Research Board, Dublin, Ireland (PNK); The Coombe Women’s Hospital, Dublin, Ireland (SFD); the Epidemiology Branch, the National Institute of Child Health and Development, the Department of Health and Human Services (JLM, MC, and CC) and the National Human Genome Research In