1. From the Departments of Health Sciences and Cell Biology, University of Jyväskylä, Jyväskylä, Finland (SC, AL, MA, QJW, MS, HS, and PHFN); the Department of Biochemistry (CL-A) and the Institute of Biomedicine and Pharmacology (RK), University of Helsinki, Helsinki, Finland; the Departments of Biochemistry and Orthopedic Surgery, Kuopio University Hospital, Kuopio, Finland (AM, SC, and HK); the C