Improved enzyme annotation with EC-specific cutoffs using DETECT v2

Author:

Nursimulu Nirvana12,Xu Leon L1,Wasmuth James D3,Krukov Ivan3,Parkinson John145

Affiliation:

1. Program in Molecular Medicine, The Hospital for Sick Children, 21–9709 PGCRL, 686 Bay Street, Toronto, ON, Canada

2. Department of Computer Science, University of Toronto, Toronto, ON, Canada

3. Department of Ecosystem and Public Health, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB, Canada

4. Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada

5. Department of Biochemistry, University of Toronto, Toronto, ON, Canada

Funder

Natural Sciences and Engineering Research Council

National Institutes of Health

SickKids RestraComp scholarship

SciNet HPC Consortium

SciNet

Canada Foundation

Government of Ontario

Ontario Research Fund–Research Excellence

Publisher

Oxford University Press (OUP)

Subject

Computational Mathematics,Computational Theory and Mathematics,Computer Science Applications,Molecular Biology,Biochemistry,Statistics and Probability

Reference11 articles.

1. Basic local alignment search tool;Altschul;J. Mol. Biol,1990

2. The ENZYME database in 2000;Bairoch;Nucleic Acids Res,2000

3. Constraint-based models predict metabolic and associated cellular functions;Bordbar;Nat. Rev. Genet,2014

4. C. elegans pharyngeal morphogenesis requires both de novo synthesis of pyrimidines and synthesis of heparan sulfate proteoglycans;Franks;Dev. Biol,2006

5. Post-genomics resources and tools for studying apicomplexan metabolism;Hung;Trends Parasitol,2011

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