Modeling positional effects of regulatory sequences with spline transformations increases prediction accuracy of deep neural networks
Author:
Affiliation:
1. Department of Informatics, Technical University of Munich, Garching, Germany
2. Graduate School of Quantitative Biosciences (QBM), Gene Center, Ludwig-Maximilians-Universität München, Munich, Germany
Funder
Deutsche Forschungsgemeinschaft
Nvidia
Publisher
Oxford University Press (OUP)
Subject
Computational Mathematics,Computational Theory and Mathematics,Computer Science Applications,Molecular Biology,Biochemistry,Statistics and Probability
Link
http://academic.oup.com/bioinformatics/article-pdf/34/8/1261/25171174/btx727.pdf
Reference41 articles.
1. Predicting the sequence specificities of DNA- and RNA-binding proteins by deep learning;Alipanahi;Nat. Biotechnol,2015
2. DeepCpG: accurate prediction of single-cell DNA methylation states using deep learning;Angermueller;Genome Biol,2017
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