Strand-seq enables reliable separation of long reads by chromosome via expectation maximization

Author:

Ghareghani Maryam123,Porubskỳ David12,Sanders Ashley D4,Meiers Sascha4,Eichler Evan E56,Korbel Jan O4,Marschall Tobias12

Affiliation:

1. Center for Bioinformatics, Saarland University, Saarland Informatics Campus E2.1, Saarbrücken, 66123, Germany

2. Max Planck Institute for Informatics, Saarland Informatics Campus E1.4, Saarbrücken, Germany

3. Graduate School of Computer Science, Saarland University, Saarland Informatics Campus E1.3, Saarbrücken, Germany

4. European Molecular Biology Laboratory (EMBL), Genome Biology Unit, Heidelberg, Germany

5. Department of Genome Sciences, University of Washington, Seattle, WA, USA

6. Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA

Funder

EEE

JOK

NIH

Howard Hughes Medical Institute

Publisher

Oxford University Press (OUP)

Subject

Computational Mathematics,Computational Theory and Mathematics,Computer Science Applications,Molecular Biology,Biochemistry,Statistics and Probability

Reference23 articles.

1. Chromosome-scale scaffolding of de novo genome assemblies based on chromatin interactions;Burton;Nat. Biotechnol,2013

2. Phased diploid genome assembly with single-molecule real-time sequencing;Chin;Nat. Methods,2016

3. Genome-wide mapping of sister chromatid exchange events in single yeast cells using strand-seq;Claussin;Elife,2017

4. Maximum likelihood from incomplete data via the EM algorithm;Dempster;J. R. Stat. Soc. Ser. B (Methodol.),1977

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