SimRVSequences: an R package to simulate genetic sequence data for pedigrees-Reference-Cited by-同舟云学术

SimRVSequences: an R package to simulate genetic sequence data for pedigrees

Published:2019-11-25 Issue:7 Volume:36 Page:2295-2297
ISSN:1367-4803
Container-title:Bioinformatics
language:en
Short-container-title:

Author:

Nieuwoudt Christina¹,Brooks-Wilson Angela²³,Graham Jinko¹

Affiliation:

1. Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, BC V5A 1S6

2. Canada’s Michael Smith Genome Sciences Centre, BC Cancer, Vancouver, BC V5Z 1L3

3. Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC V5A 1S6, Canada

Abstract

Abstract Summary We present the R package SimRVSequences to simulate sequence data for pedigrees. SimRVSequences allows for simulations of large numbers of single-nucleotide variants (SNVs) and scales well with increasing numbers of pedigrees. Users provide a sample of pedigrees and SNV data from a sample of unrelated individuals. Availability and implementation SimRVSequences is publicly-available on CRAN https://cran.r-project.org/web/packages/SimRVSequences/. Supplementary information Supplementary data are available at Bioinformatics online.

Funder

Natural Science and Engineering Research Council of Canada

Canadian Statistical Sciences Institute

Canadian Institutes of Health Research

Publisher

Oxford University Press (OUP)

Subject

Computational Mathematics,Computational Theory and Mathematics,Computer Science Applications,Molecular Biology,Biochemistry,Statistics and Probability

Link

http://academic.oup.com/bioinformatics/advance-article-pdf/doi/10.1093/bioinformatics/btz881/31561346/btz881.pdf

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