1. Metabolomics and Analytics Center, Leiden Academic Centre for Drug Research, Leiden University, Wassenaarseweg 76 , Leiden 2333 CC, The Netherlands
2. Luxembourg Centre for Systems Biomedicine, University of Luxembourg, 6 avenue du Swing , Belvaux L-4362, Luxembourg
3. School of Medicine, National University of Ireland, University Rd , Galway H91 TK33, Ireland
4. Mathematical Sciences School, University of Southampton, University Road , Southampton SO17 1BJ, United Kingdom