QuantumClone: clonal assessment of functional mutations in cancer based on a genotype-aware method for clonal reconstruction

Author:

Deveau Paul123,Colmet Daage Leo2,Oldridge Derek456,Bernard Virginie7,Bellini Angela2,Chicard Mathieu2,Clement Nathalie2,Lapouble Eve8,Combaret Valerie9,Boland Anne10,Meyer Vincent10,Deleuze Jean-Francois10,Janoueix-Lerosey Isabelle11,Barillot Emmanuel1,Delattre Olivier11,Maris John M456,Schleiermacher Gudrun212,Boeva Valentina113ORCID

Affiliation:

1. Institut Curie, PSL Research University, Mines Paris Tech, INSERM U900, Paris, France

2. Département de Recherche Translationnelle, Institut Curie, PSL Research University, INSERM U830, Laboratoire RTOP (Recherche Translationelle en Oncologie Pédiatrique), SIREDO Oncology Center (Care, Innovation and research for children and AYA with cancer), Paris, France

3. University of Paris-Sud, Orsay, France

4. Division of Oncology, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

5. Center for Childhood Cancer Research Children’s Hospital of Philadelphia, Philadelphia, PA, USA

6. Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

7. Institut Curie, PSL Research University, NGS platform ICGex, Paris, France

8. Unité de Génétique Somatique, Institut Curie, PSL Research University, Paris, France

9. Centre Léon-Bérard Laboratoire de Recherche Translationnelle, Lyon, France

10. Centre National de Recherche en Génomique Humaine (CNRGH), Institut de biologie François Jacob, CEA, Evry, France

11. Institut Curie, PSL Research University, INSERM U830, SIREDO Oncology Center (Care, Innovation and research for children and AYA with cancer), Equipe labellisée Ligue Nationale contre le cancer, Paris, France

12. Département de Pédiatrie, Institut Curie, PSL Research University, Paris, France

13. Institut Cochin, INSERM U1016, CNRS UMR 8104, Université Paris Descartes UMR-S1016, Paris, France

Funder

Annenberg Foundation

Nelia and Amadeo Barletta Foundation

ARC Foundation

Worldwide Cancer Research

National Institutes of Health

National Cancer Institute

ANR

Publisher

Oxford University Press (OUP)

Subject

Computational Mathematics,Computational Theory and Mathematics,Computer Science Applications,Molecular Biology,Biochemistry,Statistics and Probability

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