BAllC and BAllCools: efficient formatting and operating for single-cell DNA methylation data

Abstract

Abstract Motivation With single-cell DNA methylation studies yielding vast datasets, existing data formats struggle with the unique challenges of storage and efficient operations, highlighting a need for improved solutions. Results BAllC (Binary All Cytosines) emerges as a tailored format for methylation data, addressing these challenges. BAllCools, its complementary software toolkit, enhances parsing, indexing, and querying capabilities, promising superior operational speeds and reduced storage needs. Availability and implementation https://github.com/jksr/ballcools