Untangling the crosstalk between BRCA1 and R-loops during DNA repair

Author:

San Martin Alonso Marta12ORCID,Noordermeer Sylvie M12ORCID

Affiliation:

1. Leiden University Medical Center, Department of Human Genetics, Leiden, The Netherlands

2. Oncode Institute, Utrecht, The Netherlands

Abstract

Abstract R-loops are RNA:DNA hybrids assembled during biological processes but are also linked to genetic instability when formed out of their natural context. Emerging evidence suggests that the repair of DNA double-strand breaks requires the formation of a transient R-loop, which eventually must be removed to guarantee a correct repair process. The multifaceted BRCA1 protein has been shown to be recruited at this specific break-induced R-loop, and it facilitates mechanisms in order to regulate R-loop removal. In this review, we discuss the different potential roles of BRCA1 in R-loop homeostasis during DNA repair and how these processes ensure faithful DSB repair.

Funder

NWO

Publisher

Oxford University Press (OUP)

Subject

Genetics

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