ECO: the Evidence and Conclusion Ontology, an update for 2022

Author:

Nadendla Suvarna1,Jackson Rebecca1ORCID,Munro James1ORCID,Quaglia Federica23ORCID,Mészáros Bálint4ORCID,Olley Dustin1ORCID,Hobbs Elizabeth T5,Goralski Stephen M5,Chibucos Marcus1ORCID,Mungall Christopher John6ORCID,Tosatto Silvio C E3ORCID,Erill Ivan5ORCID,Giglio Michelle G1ORCID

Affiliation:

1. Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, Maryland, USA

2. Institute of Biomembranes, Bioenergetics and Molecular Biotechnologies, National Research Council (CNR-IBIOM), Bari, Italy

3. Department of Biomedical Sciences, University of Padova, Padova, Italy

4. Structural and Computational Biology Unit, European Molecular Biology Laboratory, Heidelberg 69117, Germany

5. Department of Biological Sciences, University of Maryland Baltimore County, Baltimore, Maryland, United States

6. Division of Environmental Genomics and Systems Biology, Lawrence Berkeley National Lab, Berkeley, California, USA

Abstract

Abstract The Evidence and Conclusion Ontology (ECO) is a community resource that provides an ontology of terms used to capture the type of evidence that supports biomedical annotations and assertions. Consistent capture of evidence information with ECO allows tracking of annotation provenance, establishment of quality control measures, and evidence-based data mining. ECO is in use by dozens of data repositories and resources with both specific and general areas of focus. ECO is continually being expanded and enhanced in response to user requests as well as our aim to adhere to community best-practices for ontology development. The ECO support team engages in multiple collaborations with other ontologies and annotating groups. Here we report on recent updates to the ECO ontology itself as well as associated resources that are available through this project. ECO project products are freely available for download from the project website (https://evidenceontology.org/) and GitHub (https://github.com/evidenceontology/evidenceontology). ECO is released into the public domain under a CC0 1.0 Universal license.

Funder

National Science Foundation

European Union's Horizon 2020 research and innovation

Marie Skłodowska-Curie

European Union's Horizon 2020 research and innovation program

Italian Ministry of University and Research

ELIXIR

Publisher

Oxford University Press (OUP)

Subject

Genetics

Reference24 articles.

1. Biocuration: distilling data into knowledge;International Society for Biocuration;PLoS Biol.,2018

2. ECO, the Evidence & Conclusion Ontology: community standard for evidence information;Giglio;Nucleic Acids Res.,2019

3. CollecTF: a database of experimentally validated transcription factor-binding sites in Bacteria;Kiliç;Nucleic Acids Res.,2014

4. DisProt: intrinsic protein disorder annotation in 2020;Hatos;Nucleic Acids Res.,2020

5. UniProt: the universal protein knowledgebase in 2021;UniProt Consortium;Nucleic Acids Res.,2021

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