Rhea, the reaction knowledgebase in 2022-Reference-Cited by-同舟云学术

Rhea, the reaction knowledgebase in 2022

Published:2021-11-10 Issue:D1 Volume:50 Page:D693-D700
ISSN:0305-1048
Container-title:Nucleic Acids Research
language:en
Short-container-title:

Author:

Bansal Parit¹^ORCID,Morgat Anne¹^ORCID,Axelsen Kristian B¹^ORCID,Muthukrishnan Venkatesh¹^ORCID,Coudert Elisabeth¹^ORCID,Aimo Lucila¹^ORCID,Hyka-Nouspikel Nevila¹^ORCID,Gasteiger Elisabeth¹^ORCID,Kerhornou Arnaud¹^ORCID,Neto Teresa Batista¹^ORCID,Pozzato Monica¹^ORCID,Blatter Marie-Claude¹^ORCID,Ignatchenko Alex²^ORCID,Redaschi Nicole¹^ORCID,Bridge Alan¹^ORCID

Affiliation:

1. Swiss-Prot group, SIB Swiss Institute of Bioinformatics, Centre Medical Universitaire, CH-1211 Geneva 4, Switzerland

2. EMBL-EBI European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK

Abstract

Abstract Rhea (https://www.rhea-db.org) is an expert-curated knowledgebase of biochemical reactions based on the chemical ontology ChEBI (Chemical Entities of Biological Interest) (https://www.ebi.ac.uk/chebi). In this paper, we describe a number of key developments in Rhea since our last report in the database issue of Nucleic Acids Research in 2019. These include improved reaction coverage in Rhea, the adoption of Rhea as the reference vocabulary for enzyme annotation in the UniProt knowledgebase UniProtKB (https://www.uniprot.org), the development of a new Rhea website, and the designation of Rhea as an ELIXIR Core Data Resource. We hope that these and other developments will enhance the utility of Rhea as a reference resource to study and engineer enzymes and the metabolic systems in which they function.

Funder

Swiss Federal Government

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

https://academic.oup.com/nar/article-pdf/50/D1/D693/42058388/gkab1016.pdf

Reference52 articles.

1. ChEBI in 2016: improved services and an expanding collection of metabolites;Hastings;Nucleic Acids Res.,2016

2. ExplorEnz: the primary source of the IUBMB enzyme list;McDonald;Nucleic Acids Res.,2009

3. The ENZYME database in 2000;Bairoch;Nucleic Acids Res.,2000