In silicoandin vitroevaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization-Reference-Cited by-同舟云学术

In silicoandin vitroevaluation of exonic and intronic off-target effects form a critical element of therapeutic ASO gapmer optimization

Published:2015-09-03 Issue:18 Volume:43 Page:8638-8650
ISSN:0305-1048
Container-title:Nucleic Acids Research
language:en
Short-container-title:Nucleic Acids Res

Author:

Kamola Piotr J.,Kitson Jeremy D. A.,Turner Gemma,Maratou Klio,Eriksson Sofie,Panjwani Aliza,Warnock Linda C.,Douillard Guilloux Gaelle A.,Moores Kitty,Koppe Emma L.,Wixted William E.,Wilson Paul A.,Gooderham Nigel J.,Gant Timothy W.,Clark Kenneth L.,Hughes Stephen A.,Edbrooke Mark R.,Parry Joel D.

Publisher

Oxford University Press (OUP)

Subject

Genetics

Link

http://academic.oup.com/nar/article-pdf/43/18/8638/17434372/gkv857.pdf

Reference48 articles.

1. Widespread siRNA “off-target” transcript silencing mediated by seed region sequence complementarity

2. Reduction of liver Fas expression by an antisense oligonucleotide protects mice from fulminant hepatitis

3. Antisense Drug Technology

4. Assessing unintended hybridization-induced biological effects of oligonucleotides

5. A dinucleoside phosphorothioate

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