Affiliation:
1. Department of Pharmaceutical Microbiology, School of Life Science and Technology, China Pharmaceutical University , Nanjing 210009 , China
2. State Key Laboratory of Natural Medicines, China Pharmaceutical University , Nanjing 210009 , China
Abstract
Abstract
Aims
This study aimed to investigate the probiotic effects of Acetobacter pasteurianus BP2201, isolated from brewing mass, for the treatment of alcohol-induced learning and memory ability impairments in a Caenorhabditis elegans model.
Methods and results
Acetobacter pasteurianus BP2201 was examined for probiotic properties, including acid and bile salt resistance, ethanol degradation, antioxidant efficacy, hemolytic activity, and susceptibility to antibiotics. The strain displayed robust acid and bile salt tolerance, efficient ethanol degradation, potent antioxidant activity, and susceptibility to specific antibiotics. Additionally, in the C. elegans model, administering A. pasteurianus BP2201 significantly improved alcohol-induced learning and memory impairments.
Conclusions
Acetobacter pasteurianus BP2201 proves to be a promising candidate strain for the treatment of learning and memory impairments induced by alcohol intake.
Funder
Priority Academic Program Development of Jiangsu Higher Education Institutions
Innovation and Entrepreneurship Training Program for Undergraduates of China Pharmaceutical University
Publisher
Oxford University Press (OUP)
Subject
Applied Microbiology and Biotechnology,General Medicine,Biotechnology