Severe acute respiratory syndrome coronavirus 2 indirectly damages kidney structures-Reference-Cited by-同舟云学术

Severe acute respiratory syndrome coronavirus 2 indirectly damages kidney structures

Published:2020-12 Issue:6 Volume:13 Page:1101-1104
ISSN:2048-8513
Container-title:Clinical Kidney Journal
language:en
Short-container-title:

Author:

Dargelos Mathilde¹,Couturier Aymeric¹²,Ferlicot Sophie³,Goujon Jean-Michel⁴,Roque-Afonso Anne-Marie⁵⁶,Gault Elyanne⁷,Touchard Guy⁴⁸,Ory Cecile⁴,Kaaki Sihem⁴,Vilaine Eve¹,Essig Marie¹²,Massy Ziad A¹²

Affiliation:

1. Service de Néphrologie et Dialyse, Assistance Publique–Hôpitaux de Paris (APHP), Hôpital Universitaire Ambroise Paré, Boulogne Billancourt, France

2. INSERM U1018, Equipe 5, Centre de Recherche en Epidémiologie et Santé des Populations (CESP), Université Paris Saclay et Université Versailles Saint Quentin en Yvelines, Villejuif, France

3. Service d’Anatomie Pathologique, Assistance Publique–Hôpitaux de Paris (APHP) Université Paris Saclay, Hôpital Universitaire Bicêtre, Kremlin Bicêtre, France

4. Service d’Anatomie Pathologique, Unité de microscopie électronique, Centre Hospitalo-Universitaire La Milétrie, Université de Poitiers, Poitiers, France

5. Service de Virologie, Assistance Publique–Hôpitaux de Paris (APHP), Hôpital Universitaire Paul Brousse, Villejuif, France

6. Université Paris Saclay, Villejuif, France

7. Service de Microbiologie et hygiene, Hôpitaux de Paris (APHP), Hôpital Universitaire Ambroise Paré, Boulogne Billancourt, France

8. Service de Néphrologie, Hémodialyse et Transplantation Rénale, Centre Hospitalo-Universitaire Poitiers, Poitiers, France

Abstract

Abstract Background The objectives were to characterize Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease 2019 (COVID-19) in patients with acute kidney injury (AKI). Methods Kidney biopsy samples in two Caucasian patients and one African with COVID-19 AKI were investigated. Results All patients had a high-level non-selective glomerular proteinuria. SARS-CoV-2 samples by real-time polymerase chain reaction (RT- PCR) assay were all-negative, as well as for virus particles in the kidney by electron microscopy. The three patients and patients with other AKI did not differ significantly with regard to angiotensin-converting enzyme 2 and transmembrane protease serine 2 kidney staining. Conclusions The kidney damage particularly in Caucasians in COVID-19 seems to be an AKI, possibly by the systemic inflammatory response.

Publisher

Oxford University Press (OUP)

Subject

Transplantation,Nephrology

Link

http://academic.oup.com/ckj/article-pdf/13/6/1101/35204683/sfaa209.pdf

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