APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome

Author:

Trazzi Stefania,Mitrugno Valentina Maria,Valli Emanuele,Fuchs Claudia,Rizzi Simona,Guidi Sandra,Perini Giovanni,Bartesaghi Renata,Ciani Elisabetta

Publisher

Oxford University Press (OUP)

Subject

Genetics(clinical),Genetics,Molecular Biology,General Medicine

Reference69 articles.

1. Down's syndrome: is there a decreased population of neurons?;Ross;Neurology,1984

2. Brain growth in Down syndrome subjects 15–22 weeks of gestational age and birth to 60 months;Schmidt-Sidor;Clin. Neuropathol.,1990

3. Cell cycle alteration and decreased cell proliferation in the hippocampal dentate gyrus and in the neocortical germinal matrix of fetuses with Down syndrome and in Ts65Dn mice;Contestabile;Hippocampus,2007

4. Neurogenesis impairment and increased cell death reduce total neuron number in the hippocampal region of fetuses with Down syndrome;Guidi;Brain Pathol.,2008

5. Widespread proliferation impairment and hypocellularity in the cerebellum of fetuses with Down syndrome;Guidi;Brain. Pathol.

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