Vanillic acid–Zn(II) complex: a novel complex with antihyperglycaemic and anti-oxidative activity

Author:

Oke Ifedolapo M12,Ramorobi Limpho M12,Mashele Samson S12,Bonnet Susanna L3,Makhafola Tshepiso J2,Eze Kenneth C4,Noreljaleel Anwar E M3,Chukwuma Chika I2ORCID

Affiliation:

1. Department of Health Sciences, Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein, Free State, South Africa

2. Centre for Quality of Health and Living (CQHL), Faculty of Health and Environmental Sciences, Central University of Technology, Bloemfontein, Free State, South Africa

3. Department of Chemistry, Faculty of Natural and Agricultural Sciences, University of the Free State, Bloemfontein, South Africa

4. Faculty of Medicine, Nnamdi Azikiwe University, Awka (Nnewi Campus), Anambra State, Nigeria

Abstract

Abstract Objectives Our aim was to synthesize, characterize and evaluate the antihyperglycaemic and anti-oxidative properties of a new Zn(II) complex of vanillic acid. Methods The complex was synthesized using ZnSO4.7H2O and vanillic acid as precursors. NMR and FTIR techniques were used to characterize the synthesized complex. The cytotoxicity of the complex was measured. The antihyperglycemic and anti-oxidative properties of the complex were evaluated using in vitro, cell-based and ex vivo models and compared with those of its precursors. Key findings Zn(II) coordinated with vanillic acid via a Zn(O6) coordination, with the complex having three moieties of vanillic acid. The radical scavenging, Fe3+ reducing and hepatic antilipid peroxidative activity of the complex were, respectively, 2.3-, 1.8- and 9.7-folds more potent than vanillic acid. Complexation increased the α-glucosidase and glycation inhibitory activity of vanillic acid by 3- and 2.6-folds, respectively. Zn(II) conferred potent L-6 myotube (EC50 = 20.4 μm) and muscle tissue (EC50 = 612 μm) glucose uptake effects on vanillic acid. Cytotoxicity evaluation showed that the complex did not reduce the viability of L-6 myotubes and Chang liver cells. Conclusions The data suggest that Zn(II)–vanillic acid complex had improved bioactivity relative to vanillic acid. Thus, Zn(II) may be further studied as an antihyperglycaemic and anti-oxidative adjuvant for bioactive phenolic acids.

Funder

National Research Foundation, South Africa

Central University of Technology, Bloemfontein, South Africa

Publisher

Oxford University Press (OUP)

Subject

Pharmaceutical Science,Pharmacology

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