Pseudo-AKI associated with targeted anti-cancer agents—the truth is in the eye of the filtration marker

Author:

Vanhoutte Thomas1ORCID,Sprangers Ben23ORCID

Affiliation:

1. Department of Nephrology, University Hospitals Leuven , Leuven , Belgium

2. Ziekenhuis Oost-Limburg , Genk , Belgium

3. Biomedical Research Institute, Department of Immunology and Infection , UHasselt, Diepenbeek , Belgium

Abstract

ABSTRACTBesides true acute kidney injury (AKI), the occurrence of pseudo-AKI has been associated with several targeted agents. To improve the management of cancer patients treated with targeted agents, we need to be aware of this and use diagnostic approaches to differentiate between pseudo-AKI and AKI. In an article by Wijtvliet et al. in this issue of CKJ, tepotinib is added to the list of targeted agents associated with pseudo-AKI. In this editorial we discuss the current literature regarding pseudo-AKI and true AKI associated with targeted agents, and subsequently propose a management strategy to monitor kidney function in patients treated with targeted agents.

Publisher

Oxford University Press (OUP)

Subject

Transplantation,Nephrology

Reference49 articles.

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3. Anaplastic lymphoma kinase inhibitors and their effect on the kidney;Bonilla;Clin Kidney J,2022

4. Renal effects of BRAF inhibitors: a systematic review by the Cancer and the Kidney International Network;Wanchoo;Clin Kidney J,2016

5. How to determine kidney function in cancer patients?;Sprangers;Eur J Cancer,2020

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